Search for dissertations about: "MNS"

Showing result 11 - 15 of 23 swedish dissertations containing the word MNS.

  2. 11. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS

    Author : Elin Forsgren; Jonathan Gilthorpe; Stefan Marklund; Peter Andersen; Thomas Brännström; Ulrika Nordström; Séverine Boillée; Umeå universitet; []
    Keywords : ALS; SOD1; patient-derived models; induced pluripotent stem cells; motor neurons; astrocytes; 20S proteasome low oxygen tension; misfolded SOD1; Neurology; neurologi;

    Abstract : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. READ MORE

  4. 12. Mechanisms of rhythm generation in the lamprey locomotor network

    Author : Lorenzo Cangiano; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Animals propel themselves through space, swimming, walking or flying, by rhythmic oscillatory movements of their body and limbs. In vertebrates these movements are mainly generated by specialized neuronal circuits in the spinal cord, called central pattern generators (CPGs) for locomotion. READ MORE

  5. 13. Fatigue Anisotropy in Forged Components

    Author : Cornelius Temmel; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Inclusion Cluster; Low Sulfur; Machinability; Inclusion; Manganese Sulfide; Quenching Crack; Forging; Isotropic Quality; Steel; Anisotropy;

    Abstract : Ever-growing requirements on combustion engine efficiency of motor vehicles demand increasing service loads in powertrain components. Optimization of component material is therefore inevitable. A major detriment with many forged transmission components is their anisotropic mechanical behavior, not least during cyclic loading. READ MORE

  6. 14. Neuronal mechanisms of feedback postural control

    Author : Li-Ju Hsu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : postural control; equilibrium; body configuration; reticulospinal neurons; stretch receptor neurons; galvanic vestibular stimulation; artificial feedback; locomotion; spinalization; rabbit; lamprey;

    Abstract : Different species maintain a basic body posture due to the activity of the postural control system. An efficient control of the body orientation, as well as the body configuration, is important for standing and during locomotion. READ MORE

  7. 15. Generation of cell diversity in the developing brainstem and its modeling in vitro

    Author : Mariya Kozhevnikova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional and temporal patterning provides a basic framework for how the developing brain can be functionally assembled, and the growing knowledge about these patterning mechanisms offer a powerful tool to effectively control the differentiation of pluripotent stem cells (PSCs) into different neuronal subtypes of clinical importance. READ MORE