Search for dissertations about: "MPTP"

Showing result 1 - 5 of 13 swedish dissertations containing the word MPTP.

  1. 1. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Ekesbo; Uppsala universitet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; positron emission tomography; 6-OHDA; MPTP; dyskinesia; dopaminergic degeneration; - -OSU6162; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; Neurology; neurologi;

    Abstract : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. READ MORE

  2. 2. MPTP-induced behavioural deficits in mice : validity and utility of a model of Parkinsonism

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Fredriksson; Uppsala universitet.; [1994]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  3. 3. Melanin binding of MPTP and related substances, and manganese : possible connection with parkinsonism

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Annika Lydén Sokolowski; Uppsala universitet.; [1990]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 4. Neuronal dysfunction, death and repair in the MPTP model of Parkinson´s disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Neuroscience

    Author : Kioumars Delfani; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; apoptosis; substantia nigra; dopamine; MPTP; neurogenesis; intracranial transplantation; ATP; PET; stereology; diethyldithiocarbamate; 7-nitroindazole; mouse; squirrel monkey; non- human primate;

    Abstract : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6- tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. READ MORE

  5. 5. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia

    University dissertation from Department of Experimental Medical Science, Lund Univeristy

    Author : Daniella Rylander; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Dyskinesia; L-DOPA; 6-OHDA rat model; MPTP monkey model; glutamate; serotonin; DA.; 5-HT;

    Abstract : Popular Abstract in Swedish Parkinsons sjukdom är en av våra vanligaste ålderssjukdomar i Sverige och drabbar en procent av befolkningen över 50 år. De karaktäristiska symptomen: skakningar, långsamma rörelser och stelhet orsakas i huvudsak av en förlust av nervceller som producerar signalsubstansen dopamin i hjärnan. READ MORE