Search for dissertations about: "MRD"

Showing result 21 - 25 of 35 swedish dissertations containing the word MRD.

2. 21. Gene Expression Studies of Hematologic Malignacies

   Author : Anna Andersson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

   Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE

4. 22. Predictors of prognosis in acute myeloid leukemia : a clinical and epidemiological study

   Author : Åsa Rangert Derolf; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : AML is a malignant disorder characterized by clonal expansion of immature myeloid hematopoietic stem cells, myeloblasts, in bone marrow, blood and/or other tissue. Despite advances in treatment the majority of patients eventually die from this aggressive disease. READ MORE

5. 23. Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors

   Author : Charlotta Andersson; Eva Lundin; Aihong Li; Andreas Jonsson; Xingru Li; David M. Loeb; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms’ tumor gene 1; biomarker; leukemia; renal cell carcinoma; ovarian carcinoma; Clinical Chemistry; klinisk kemi; patologi; Pathology;

   Abstract : Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. READ MORE

6. 24. Clinical and epidemiological studies of haemophagocytic lymphohistiocytosis

   Author : AnnaCarin Horne; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Haemophagocytic lymphohistiocytosis; treatment; hematopoietic stem cell transplant; lymphocyte cytotoxicity; central nervous system; neurological symptoms; genotype-phenotype;

   Abstract : Haemophagocytic lymphohistiocytosis (HLH) comprises primary (inherited) and secondary forms. The primary forms typically present in young children and carry a very high risk of mortality. The secondary forms, which are the result of different disorders, can present in all ages with greatly varying symptoms. READ MORE

7. 25. IKAROS and LEUKEMIA

   Author : Linda Olsson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric acute lymphoblastic leukemia; relapse; risk-stratifying factors; IKZF1; cooperative changes;

   Abstract : Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. READ MORE