Search for dissertations about: "MSI"

Showing result 1 - 5 of 59 swedish dissertations containing the word MSI.

  1. 1. Genetic and epidemiological studies of hereditary colorectal cancer

    Author : Kristina Cederquist; Henrik Grönberg; Irina Golovleva; Gösta Holmgren; Mef Nilbert; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lynch syndrome; HNPCC; colorectal cancer; endometrial cancer; cancer risk; MSI; MLH1; MSH2; MSH6; genome-wide scan; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

    Abstract : Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC) is the most common hereditary syndrome predisposing to colorectal cancer, accounting for 1-3% of all colorectal cancer. This multi-organ cancer predisposition syndrome is caused by mutations in the mismatch repair (MMR) genes, especially MLH1 and MSH2, and to lesser extents MSH6 and PMS2, which lead to widespread genetic instability and thus microsatellite instability (MSI). READ MORE

  2. 2. Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer

    Author : Jenny Brändstedt; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; carcinogenesis; MDCS; anthropometrics; risk factors; sex differences; hormonal therapy; beta-catenin; cyclin D1; p53; MSI; KRAS mutation; BRAF mutation;

    Abstract : Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. READ MORE

  3. 3. Metabolic Risk Factors and Molecular Subtypes of Colorectal Cancer

    Author : Robin Myte; Bethany van Guelpen; Richard Palmqvist; Jenny Häggström; Matty Weijenberg; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; risk factors; metabolic syndrome; one-carbon metabolism; molecular subtypes; KRAS; BRAF; MSI; molecular pathological epidemiology; Cancer Epidemiology; cancerepidemiologi;

    Abstract : Background: Colorectal cancer (CRC) is a heterogeneous disease developing from distinct pathways, resulting in tumor subtypes with large differences in clinical and molecular characteristics. Molecular characteristics are increasingly being used clinically to guide therapy. READ MORE

  4. 4. Applications of nanospray desorption electrospray ionization mass spectrome : Analysis of lipids and metabolites in brain tissue sections and single cells

    Author : Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Leopold Ilag; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Nano-DESI; single cell analysis; small molecule neurotransmitters; mass spectrometry imaging; MSI; GABA; Glutamate; Acetylcholine; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : .... READ MORE

  5. 5. Orthodontic anchorage with miniscrews : towards new possibilities

    Author : Niels Ganzer; Malmö universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Orthodontics; Orthodontic anchorage procedures; Miniscrew; TAD; Miniimplant; MSI; Anchorage Capacity; Patients´ Perception; Health Economics;

    Abstract : .... READ MORE