Search for dissertations about: "Magnus Wolf-Watz"

Showing result 1 - 5 of 10 swedish dissertations containing the words Magnus Wolf-Watz.

  2. 1. Structure-function relationships of the human Runx1 transcription factor

    Author : Magnus Wolf-Watz; KTH; []
    Keywords : Runx1; Runt domain; CBFâ; transcription; leukemia; protein structure; protein dynamics;

    Abstract : Runx transcription factors contain a DNA-binding andtransactivating α-subunit and a β-subunit (CBFβ)that serves to increase the DNA binding affinity of theα-subunit. The DNA binding domain of Runx proteins isnamed the Runt homology domain (RD) after its strong sequencehomology to theDrosophilaprotein Runt. READ MORE

  4. 2. Modulation of amyloid β peptide self-assembly : Aggregation mechanisms associated with Alzheimer's disease

    Author : Axel Abelein; Astrid Gräslund; Magnus Wolf-Watz; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Abstract : .... READ MORE

  5. 3. The role of RNA in prion aggregation and disease

    Author : Petar Stefanov Kovachev; Suparna Sanyal; Per Jemth; Magnus Wolf-Watz; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : As humanity evolved to witness an exceptionally high standard of living, Alzheimer’s, cancer and diabetes gradually replaced infections as the main limiting factors in longevity. It is both disturbing and captivating that such degenerative conditions are caused by the most ubiquitous biomolecule – the protein. READ MORE

  6. 4. How transient interactions in the crowded cytosol affect protein mobility and stability

    Author : Sarah Leeb; Mikael Oliveberg; Magnus Wolf-Watz; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; diffusive transient interactions; macromolecular crowding; protein stability; in-cell NMR; protein evolution; Biophysics; biofysik;

    Abstract : Most biochemical reactions have evolved in crowded intracellular environments. However, the complexity of intracellular environments is often neglected in structural or functional studies of proteins. READ MORE

  7. 5. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

    Author : Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

    Abstract : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. READ MORE