Search for dissertations about: "Magnus Wolf-Watz"

Showing result 6 - 10 of 14 swedish dissertations containing the words Magnus Wolf-Watz.

  2. 6. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

    Author : Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

    Abstract : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. READ MORE

  4. 7. The role of the mitochondrial membrane system in apoptosis : the influence of oxidative stress on membranes and their interactions with apoptosis-regulating Bcl-2 proteins

    Author : Martin Lidman; Gerhard Gröbner; Magnus Wolf-Watz; Philip Williamson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bax; Bc-2; apoptosis; mitochondria; membranes; oxidized lipids; NMR; calorimetry; circular dichroism; biokemi; Biochemistry; fysikalisk kemi; Physical Chemistry;

    Abstract : Apoptosis is a crucial process in multicellular organisms in sculpting them, especially during embryogenesis. In addition, apoptosis is responsible for the clearance of harmful or damaged cells which can otherwise be detrimental to the organism. READ MORE

  5. 8. FtsH metalloproteases and their pseudo-proteases in the chloroplast envelope of Arabidopsis thaliana

    Author : Laxmi S. Mishra; Christiane Funk; Magnus Wolf-Watz; Catherine de Vitry; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Arabidopsis thaliana; AAA-ATPases; abscisic acid; chloroplast; drought; embryo-lethal; FtsH metalloprotease; intrinsic water-use efficiency WUEi ; leaf variegation; outdoor conditions; oxidative stress; plastid biogenesis; proteomics; protein import; root-associated bacterial communities seedlings; Biochemistry; biokemi; molekylärbiologi; Molecular Biology; biology; biologi;

    Abstract : By cleaving peptide bonds, proteases either activate or degrade proteins and maintain protein quality control in response to various developmental stimuli and environmental factors. My work has focused on elucidating the role of the filamentation temperature sensitive protein H (FtsH) proteases. READ MORE

  6. 9. Regulation of the multi-functional protein YscU in assembly of the Yersinia type III secretion injectisome

    Author : Ho Ngoc Hoang Oanh; Magnus Wolf-Watz; Anna Linusson Jonsson; Maria Sunnerhagen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system T3SS ; injectisome; Yersinia pseudotuberculosis; inhibitors; Yops; YscU; YscP; YscI; disorder-to-order transition; nuclear magnetic resonance NMR ; circular dichroism CD ; isothermal titration calorimetry ITC ; biologisk kemi; biological chemistry;

    Abstract : Yersinia pseudotuberculosis is a Gram-negative zoonotic pathogenic bacterium causing gastroenteritis in human and animals. It shares a conserved virulence plasmid encoding for a needle-like secretion machinery, or type III secretion system, which can be found in other pathogenic Gram-negative bacteria. READ MORE

  7. 10. Functional dynamics of glycosyltransferases : Solution-state NMR studies of peripheral membrane proteins involved in glycolipid biosynthesis in bacteria

    Author : Joan Patrick; Lena Mäler; Magnus Wolf-Watz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Abstract : Antibiotic resistance is an existential threat enabled by bacterial adaptation and fuelled by inappropriate use of medication. The ensuing shortage of effective treatments has led to a rise in deaths linked to resistant bacterial pathogens. READ MORE