Search for dissertations about: "Malaria africa"

Showing result 11 - 15 of 63 swedish dissertations containing the words Malaria africa.

  2. 11. Modelling and Simulation to Improve Antimalarial Therapy

    Author : Jesmin Permala Lohy Das; Mats Karlsson; Martin Bergstrand; Joel Tarning; Mads Krielgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE

  4. 12. New strategies and tools for Plasmodium falciparum case management and surveillance in the era of imminent resistance to artemisinin-based combination therapy in Tanzania

    Author : Lwidiko E Mhamilawa; Andreas Mårtensson; Billy Ngasala; Ulrika Morris; Ib Christian Bygbjerg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malaria; Plasmodium falciparum; artemether-lumefantrine; drug resistance; Tanzania; Medicinsk vetenskap; Medical Science;

    Abstract : Artemether-lumefantrine has been an efficacious first line treatment for uncomplicated Plasmodium falciparum malaria in Tanzania since its introduction in 2006. Interest has developed in understanding the observation of high residual PCR determined positivity rates on day 3 after supervised artemether-lumefantrine treatment in the magnitude of almost 30% in previous assessments from 2015 in Bagamoyo district, Tanzania. READ MORE

  5. 13. Acute febrile illness in preschool children in Zanzibar - Infectious aetiologies, diagnosis and treatment

    Author : Kristina Elfving; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Children; Infections; Low-income country; Tanzania; malaria; pneumonia; antibiotics; fever; diagnosis; polymerase chain reaction; preschool; influenza virus; Respiratory syncytial virus; diarrhoea; norovirus; dengue virus;

    Abstract : Background: A majority of the three million children in Africa that do not survive their fifth birthday die from infections that often start as a seemingly uncomplicated febrile illness. Primary health care workers frequently encounter febrile children with a negative malaria rapid diagnostic test (mRDT), in particular in places like Zanzibar with a considerable decline in malaria prevalence. READ MORE

  6. 14. Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics

    Author : Mohd Yusmaidie Aziz; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioanalysis; Pharmacokinetics; Piperaquine; Malaria;

    Abstract : Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. READ MORE

  7. 15. LIVING WITH PARASITES: AVIAN MALARIA, TELOMERE LENGTH AND LIFE HISTORY TRADE-OFFS

    Author : Asghar Muhammad; MEMEG; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Avian malaria; Plasmodium; qPCR; parasitemia; life history; reproduction; survival; feather growth; MHC; telomere length; heritability; telomere loss; fitness; wild population; Acrocephalus arundinaceus; Delichon urbica;

    Abstract : Haemosporidia is a well-studied group of parasites, which infect mammals, reptiles and birds and use blood sucking vectors for their transmission. By conducting natural population studies and experimental infections, We have been able to detect and quantify Haemosporidia from avian blood to investigate how these pathogens affect their avian hosts. READ MORE