Search for dissertations about: "Malin Darnell"

Found 1 swedish dissertation containing the words Malin Darnell.

2. 1. Human liver in vitro models for evaluation of drug metabolism and disposition

   Author : Malin Darnell; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The administrated dose of a drug is adjusted to give a therapeutic effect in patients without causing side-effects or toxicity. Cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes, uptake and efflux transporters and nuclear receptors regulating these enzymes, expressed in the liver and in other tissues, are all important players in drug metabolism, disposition and elimination. READ MORE