Search for dissertations about: "Mantle"

Showing result 1 - 5 of 122 swedish dissertations containing the word Mantle.

  2. 1. Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering

    Author : Usama M. Hegazy; Bengt Mannervik; Mikael Widersten; T. J. Mantle; Uppsala universitet; []
    Keywords : Biochemistry; Glutathione transferase; targeted chemical modification; lock-and-key motif; cooperativity; stucture-function relationship; protein engineering; unnatural amino acid; site-specific mutation; Biokemi;

    Abstract : The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of GSTP1-1. READ MORE

  4. 2. Modulating Enzyme Functions by Semi-Rational Redesign and Chemical Modifications : A Study on Mu-class Glutathione Transferases

    Author : Malena A Norrgård; Bengt Mannervik; Birgitta Tomkinson; Timothy Mantle; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein redesign; semi-rational redesign; saturation mutagenesis; iterative saturation mutagenesis; chemical modification; Cys; Cys-X scanning; enzyme evolution; promiscuous; substrate selectivity; enantioselectivity; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Today, enzymes are extensively used for many industrial applications, this includes bulk and fine-chemical synthesis, pharmaceuticals and consumer products. Though Nature has perfected enzymes for many millions of years, they seldom reach industrial performance targets. READ MORE

  5. 3. In vivo- and in vitro-studies of hormonal regulation of cytosolic glutathione transferases : effects of growth hormone, adrenocorticotrophic hormone, thyroid hormone and testosterone

    Author : Louise Staffas; Tim Mantle; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : .... READ MORE

  6. 4. Mantle cell lymphoma strategies in primary treatment

    Author : Alexandra Albertsson Lindblad; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mantle cell lymphoma; registry data; Clinical Trial; Phase I; Clinical Trial; Phase II; rituximab; bendamustine; lenalidomid; ibrutinib; ADCC; in vitro model; TP53 mutations; watchful waiting; mantle cell lymphoma; real-world data; lenalidomide; rituximab; bendamustin; ibrutinib; ADCC; TP53 mutation; CDKN2A; NGS; MIPI; Watchful waiting;

    Abstract : Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. READ MORE

  7. 5. Origin of the Kleva Ni-Cu sulphide mineralisation in Småland, southeast Sweden

    Author : Karolina Bjärnborg; Berggrundsgeologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Palaeoproterozoic; Fennoscandia; geochronology; geochemistry; sulphide remobilisation; gabbro–diorite; mantle; arc; ore genesis; Ni-Cu sulphide deposit;

    Abstract : The Kleva Ni-Cu sulphide deposit is situated within a gabbro-diorite intrusive complex in southeast Sweden. The basement north of the intrusive complex is dominated by 1.81–1.77 Ga granites of the Palaeoproterozoic Transscandinavian Igneous Belt (TIB). READ MORE