Search for dissertations about: "Margareta Fredriksson"

Found 1 swedish dissertation containing the words Margareta Fredriksson.

  1. 1. Hyperreactive peripheral neutrophils in periodontitis : FCc receptor activation and plasma proteins

    Author : Margareta Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Periodontitis neutrophils; oxygen radicals; smoking; priming.;

    Abstract : It is now well established that adult and juvenile periodontitis are associated with a hyperreactivity of the peripheral neutrophils when measured as increased generation of free oxygen radicals after stimulation of the Fcgamma-receptors. Aim: The aims of these investigations were to study if the increased radical generation was: 1) located intra- or extracellularly and attributed to a specific oxygen species or various activation pathways, 2) connected with "priming" (pre-stimulation only disclosed by a secondary activation), 3) associated with systemic aberrations in plasma parameters induced by the periodontal disease or cigarette smoking or 4) related to the neutrophil production of the cytokines IL-8 and TNFalpha after stimulation. READ MORE