Search for dissertations about: "Maria Sunnerhagen"

Showing result 1 - 5 of 8 swedish dissertations containing the words Maria Sunnerhagen.

  1. 1. Structural insights into protein-protein interactions governing regulation in transcription initiation and ubiquitination

    Author : Madhanagopal Anandapadamanaban; Maria Sunnerhagen; Martin Moche; Marie Wahren-Herlenius; Cynthia Wolberger; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Virtually every aspect of the cellular processes in eukaryotes requires that the interactions between protein molecules are well coordinated in different regulatory pathways. Any protein dysfunction involved in these regulatory pathways might lead to various pathological conditions. READ MORE

  2. 2. Protein Structure and Interaction in Health and Disease

    Author : Cecilia Andrésen; Maria Sunnerhagen; Patrik Lundström; Lena Mäler; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : This thesis focuses on protein structure, dynamics and interaction and their relation to human disease. In particular, the biophysical and structural properties of both well-ordered and partially disordered proteins are studied using a range of biophysical techniques such as circular dichroism spectroscopy, fluorescence spectroscopy, mass spectrometry and nuclear magnetic resonance spectroscopy. READ MORE

  3. 3. Structural biology of transcriptional regulation in the c-Myc network

    Author : Sara Helander; Maria Sunnerhagen; Patrik Lundström; Lila M. Gierasch; Linköpings universitet; []
    Keywords : ;

    Abstract : The oncogene c-­‐Myc is overexpressed in many types of human cancers and regulation of c-­‐Myc expression is crucial in a normal cell. The intrinsically disordered N-­‐terminal transactivation domain interacts with a wide range of proteins regulating c-­‐Myc activity. READ MORE

  4. 4. Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases

    Author : Janosch Hennig; Maria Sunnerhagen; Kylie J. Walters; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Abstract : Several members of the tripartite motif (TRIM) protein family are involvedin antiviral activity and immunity and have been linked to severaldiseases. TRIM21, the main object of this thesis, is involved in Sjögrensyndrome (SS) and systemic lupus erythematosus (SLE), where patientsoften have autoantibodies against different epitopes on TRIM21. READ MORE

  5. 5. Regulation of the multi-functional protein YscU in assembly of the Yersinia type III secretion injectisome

    Author : Ho Ngoc Hoang Oanh; Magnus Wolf-Watz; Anna Linusson Jonsson; Maria Sunnerhagen; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Type III secretion system T3SS ; injectisome; Yersinia pseudotuberculosis; inhibitors; Yops; YscU; YscP; YscI; disorder-to-order transition; nuclear magnetic resonance NMR ; circular dichroism CD ; isothermal titration calorimetry ITC ; biologisk kemi; biological chemistry;

    Abstract : Yersinia pseudotuberculosis is a Gram-negative zoonotic pathogenic bacterium causing gastroenteritis in human and animals. It shares a conserved virulence plasmid encoding for a needle-like secretion machinery, or type III secretion system, which can be found in other pathogenic Gram-negative bacteria. READ MORE