Search for dissertations about: "Maria T. Lindgren"

Found 1 swedish dissertation containing the words Maria T. Lindgren.

2. 1. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

   Author : Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

   Abstract : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. READ MORE