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Found 5 swedish dissertations matching the above criteria.

2. 1. The Duodenal Mucosal Bicarbonate Secretion : Role of Melatonin in Neurohumoral Control and Cellular Signaling

   Author : Markus Sjöblom; Gunnar Flemström; Olof Nylander; Karl EO Åkerman; Per M. Hellström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; alkaline secretion; central nervous system; duodenal enterocyte; duodenal ulcer; duodenum; enterochromaffin cell; human; intraarterial; intracellular calcium; intracerebroventricular; melatonin; rat; vagal nerve; Fysiologi; Physiology; Fysiologi;

   Abstract : The duodenal lumen is exposed to aggressive factors with a high potential to cause damage to the mucosa. Bicarbonate secretion by the duodenal mucosa is accepted as the primary important defense mechanism against the hydrochloric acid intermittently expelled from the stomach. READ MORE

4. 2. Experimental Disruption of Intestinal Mucosal Homeostasis : Exploring the Protective Potential of Melatonin and Misoprostol

   Author : Karsten Peters; Markus Sjöblom; Hans Lennernäs; David Dahlgren; Åsa Keita; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestinal barrier dysfunction; intestinal permeability; chemotherapy-induced mucositis; doxorubicin; 5-fluorouracil; apoptosis; proliferation; melatonin; misoprostol; Medicinsk vetenskap; Medical Science;

   Abstract : The intestinal mucosa serves as a protective layer that separates the intestinal contents from the underlying tissues. It restricts harmful substances, pathogens, and undigested particles from entering the bloodstream. READ MORE

5. 3. Prevention of Postoperative Duodenal Ileus by COX-2 Inhibition Improves Duodenal Function in Anaesthetised Rats

   Author : John Sedin; Olof Nylander; Markus Sjöblom; Lars Fändriks; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; duodenum; motility; enteric nervous system; luminal alkalinisation; CFTR; VIP; luminal Cl-; fluid secretion; solute absorption; mucosal permeability; 51Cr-EDTA; luminal osmolality; luminal hypertonicity; glucose; mannitol; orange juice; parecoxib; hexamethonium; mecamylamine; Physiology; Fysiologi;

   Abstract : Abdominal surgery inhibits gastrointestinal motility, a phenomenon referred to as postoperative ileus. Since the postoperative ileus disturbs duodenal physiology it is important to minimize the side effects of this condition. READ MORE

6. 4. Regulation of Duodenal Mucosal Barrier Function and Motility : The Impact of Melatonin

   Author : Anna Sommansson; Markus Sjöblom; Olof Nylander; Oliver Bachmann; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; bicarbonate secretion; duodenum; enteric nervous system; enterochromaffin cell; ethanol; hexamethonium; in vivo; mecamylamine; motility; mucosal permeability; parecoxib; rat; Physiology; Fysiologi;

   Abstract : The duodenal mucosa is regularly exposed to acid, digestive enzymes and ingested noxious agents. It is thus critical to maintain a protective barrier to prevent the development of mucosal injury and inflammation, which are often observed in situations when barrier function is impaired. READ MORE

7. 5. Role of Melatonin, Neuropeptide S and Short Chain Fatty Acids in Regulation of Duodenal Mucosal Barrier Function and Motility

   Author : Wan Salman Wan Saudi; Markus Sjöblom; Olof Nylander; Mark Berner-Hansen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; rat; in vivo; duodenum; enteric nervous system; paralytic ileus; parecoxib; bicarbonate secretion; motility; ethanol; HCl; melatonin; neuropeptide S; short chain fatty acids; chemosensing; Physiology; Fysiologi;

   Abstract : The duodenal epithelium is regularly exposed to HCl, digestive enzymes, bacteria and toxins, and sometimes also to ethanol and drugs. The imbalance of aggressive factors in the intestinal lumen and mucosal barrier function increases the risk of tissue injury and inflammation. READ MORE