Search for dissertations about: "Martha-lena Müller"

Found 1 swedish dissertation containing the words Martha-lena Müller.

2. 1. Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis

   Author : Martha-Lena Müller; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined how certain missense mutations in genes encoding syntaxin-11 and Munc18-2 abolish exocytosis and cause disease. READ MORE