Search for dissertations about: "Matematiska vetenskaper"

Showing result 1 - 5 of 293 swedish dissertations containing the words Matematiska vetenskaper.

  2. 1. Modelling of drug-effect on time-varying biomarkers

    Author : Felix Held; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cortisol; TNFα; hierarchical modelling; turnover model; pharmacokinetic pharmacodynamic modelling; cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling;

    Abstract : Model-based quantification of drug effect is an efficient tool during pre-clinical and clinical phases of drug trials. Mathematical modelling can lead to improved understanding of the underlying biological mechanisms, help in finding shortcomings of experimental design and suggest improvements, or be an effective tool in simulation-based analyses. READ MORE

  4. 2. Data-driven modeling of combination therapy in oncology

    Author : Tim Cardilin; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling; Nonlinear Mixed-Effects Models;

    Abstract : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. READ MORE

  5. 3. Embedding theorems for spaces with multiweighted derivatives

    Author : Zamira Abdikalikova; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Matematik; Mathematics;

    Abstract : This Licentiate Thesis consists of four chapters, which deal with a new Sobolev type function space called the space with multiweighted derivatives. This space is a generalization of the usual one dimensional Sobolev space. READ MORE

  6. 4. Some new results concerning boundedness and compactness for embeddings between spaces with multiweighted derivatives

    Author : Zamira Abdikalikova; Victor Burenkov; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mathematics; Matematik;

    Abstract : This Doctoral Thesis consists of five chapters, which deal with a new Sobolev type function space called the space with multiweighted derivatives. This space is a generalization of the usual one dimensional Sobolev space. As basis for this space serves some differential operators containing weight functions. READ MORE

  7. 5. Coercive estimates for the solutions of some singular differential equations and their applications

    Author : Raya Akhmetkaliyeva; Gabriela Holubová; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Matematik; Mathematics;

    Abstract : This Licentiate thesis deals with the study of existence and uniqueness together with coercive estimates for solutions of certain differential equations. The thesis consists of four papers (papers A, B, C and D) and an introduction, which put these papers into a more general frame and which also serves as an overview of this interesting field of mathematics. READ MORE