Search for dissertations about: "Mathias Uhlén"

Showing result 1 - 5 of 19 swedish dissertations containing the words Mathias Uhlén.

  1. 1. Metabolic engineering strategies to increase n-butanol production from cyanobacteria

    Author : Josefine Anfelt; Elton P. Hudson; Mathias Uhlén; Patrik R. Jones; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; cyanobacteria; metabolic engineering; biofuels; butanol; synthetic scaffold; CRISPRi; solvent tolerance; Biotechnology; Bioteknologi;

    Abstract : The development of sustainable replacements for fossil fuels has been spurred by concerns over global warming effects. Biofuels are typically produced through fermentation of edible crops, or forest or agricultural residues requiring cost-intensive pretreatment. READ MORE

  2. 2. Selection of antigens for antibody-based proteomics

    Author : Lisa Berglund; Mathias Uhlén; Sören Brunak; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; epitope; antigen; antibody; affinity; protein; proteome; proteomics; bioinformatics; prediction; primer design; sequence similarity; Bioengineering; Bioteknik;

    Abstract : The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the key players in the body, but the functions and localizations of most proteins are still unknown. READ MORE

  3. 3. Databases for antibody-based proteomics

    Author : Erik Björling; Mathias Uhlén; Alvis Brazma; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; proteomics; antibodies; database; biomarker; website; Bioengineering; Bioteknik;

    Abstract : Humans are believed to have ~20,500 protein-coding genes andmuch effort has over the last years been put into the characterizationand localization of the encoded proteins in order to understand theirfunctions. One such effort is the Human Proteome Resource (HPR)project, started in Sweden 2003 with the aim to generate specificantibodies to each human protein and to use those antibodies toanalyze the human proteome by screening human tissues and cells. READ MORE

  4. 4. Synthetic biology approaches for improving production of fatty acid-derived compounds in cyanobacteria

    Author : Ivana Cengic; Elton P. Hudson; Mathias Uhlén; Annegret Wilde; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; cyanobacteria; metabolic engineering; surface display; CRISPRi; fatty alcohols; fatty acid synthesis; aldehyde deformylating oxygenase; Biotechnology; Bioteknologi;

    Abstract : The environmental consequences associated with the use of fossil-sourced fuels and chemicals have brought with it a realization that future development must move in a more sustainable direction. Currently available biofuels or renewably produced chemical, such as bioethanol or biodiesel, are produced from microbial fermentation of sugar-rich crops or by chemical conversion of natural oils or fats. READ MORE

  5. 5. Integration of RNA and protein expression profiles to study human cells

    Author : Frida Danielsson; Emma Lundberg; Mikael Huss; Mathias Uhlén; Christine Vogel; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; RNA-seq; Transcriptomics; Proteomics; Malignant transformation; Cancer; Functional enrichment; Biotechnology; Bioteknologi; Medicinsk teknologi; Medical Technology;

    Abstract : Cellular life is highly complex. In order to expand our understanding of the workings of human cells, in particular in the context of health and disease, detailed knowledge about the underlying molecular systems is needed. READ MORE