Search for dissertations about: "Matrix assisted laser desorption ionization"

Showing result 6 - 10 of 55 swedish dissertations containing the words Matrix assisted laser desorption ionization.

  2. 6. Label free analysis and spatial distribution of molecular lipids in brain tissue and cells using mass spectrometry imaging

    Author : Amir Saeid Mohammadi; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry Imaging; Secondary Ion Mass Spectrometry Imaging; Matrix Assisted Laser desorption Ionization; Lipids; Brain tissue;

    Abstract : Lipids are important inherent components in brain and cell membranes, which play significant biological roles in cell function. Identification and localization of specific biomolecules such as peptides and lipids within cellular membranes is currently a major challenge in metabolomics and biological studies. READ MORE

  4. 7. Engineering of thermometric biosensors and characterisation of redox enzymes for improved performance of biosensors/biofuel cells

    Author : Maria Yakovleva; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Flow injection analysis; thermometric calorimetric biosensor; enzyme thermistor; immobilised enzyme reactor; amperometric biosensor; enzymatic biofuel cell; bioanode; pyranose dehydrogenase; cellobiose dehydrogenase; direct electron transfer; mediated electron transfer; matrix-assisted laser desorption ionization; glycosite mapping;

    Abstract : The present work is mainly focused on the development of enzyme-based bioanalytical devices, which can further be applied as analytical tools for industrial, medical and environmental applications. The first part of the work deals with the practical applications of thermometric biosensors for determination of various sugars (fructose and lactose) in a real samples. READ MORE

  5. 8. Electrophoretic focusing in microchannels combined with mass spectrometry : Applications on amyloid beta peptides

    Author : Saara Mikkonen; Åsa Emmer; Johan Jacksén; Tapio Kotiaho; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

    Abstract : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. READ MORE

  6. 9. Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease

    Author : Wojciech Michno; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; beta-amyloid; electron microscopy; imaging mass spectrometry; lipids; luminescent conjugated oligothiophenes; matrix-assisted laser desorption ionization mass spectrometry MALDI-MS ; molecular imaging; nanoscale secondary ion mass spectrometry NanoSIMS ; neurodegeneration; peptides;

    Abstract : Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired amyloid-positive (CU-AP) individuals, but these Aβ plaques are primarily diffuse in structure. READ MORE

  7. 10. Novel Solid Phase Extraction and Mass Spectrometry Approaches to Multicomponent Analyses in Complex Matrices

    Author : Nahid Amini; Gunnar Thorsén; Tuulia Hyötyläinen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sample preparation; SPE; RAM; GCB µ-trap; GCB disk; High temperature LC; LC MS; ESI; APCI; Matrix effects; LIT-MS; SALDI; Sample screening; Oxidized GCB; Silicon nitride; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : Analysis of compounds present in complex matrices is always a challenge, which can be partly overcome by applying various sample preparation techniques prior to detection. Ideally, the extraction techniques should be as selective as possible, to minimize the concentration of interfering substances. READ MORE