Search for dissertations about: "Mats Gustafsson"

Showing result 16 - 20 of 38 swedish dissertations containing the words Mats Gustafsson.

  2. 16. Fusing Domain Knowledge with Data : Applications in Bioinformatics

    Author : Claes Andersson; Jan Komorowski; Mats Gustafsson; Yves Moreau; Uppsala universitet; []
    Keywords : Bioinformatics; cell cycle; cancer chemotherapy; predictive tests; performance estimation; bioinformatics; Bioinformatik;

    Abstract : Massively parallel measurement techniques can be used for generating hypotheses about the molecular underpinnings of a biological systems. This thesis investigates how domain knowledge can be fused to data from different sources in order to generate more sophisticated hypotheses and improved analyses. READ MORE

  4. 17. Characterization of Biomolecular Interactions Using a Multivariate Approach

    Author : Karl Andersson; Mats Gustafsson; Jörgen Carlsson; Olav Kvalheim; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Chemometrics; QSAR; Interaction; kinetics; Biokemi; Biochemistry; Biokemi;

    Abstract : This thesis presents a novel bioinformatic methodology denoted the bio-chemometric approach. The methodology is designed for generation of detailed descriptions and predictions of biomolecular interactions. It is based on multivariate analysis of the sensitivity of a biomolecular interaction to multiple minor changes in the experimental conditions. READ MORE

  5. 18. Optimal Detectors for Transient Signal Families and Nonlinear Sensors : Derivations and Applications

    Author : Daniel Asraf; Mats Gustafsson; Anders Grennberg; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Signalbehandling; optimal detection; transient signals; noncoherent detection; unknown arrival time; ultrasonic nondestructive testing; nonlinear sensor; stochastic resonance; Signalbehandling; Signal processing; Signalbehandling; Signal Processing; signalbehandling;

    Abstract : This thesis is concerned with detection of transient signal families and detectors in nonlinear static sensor systems. The detection problems are treated within the framework of likelihood ratio based binary hypothesis testing. READ MORE

  6. 19. Machine Learning Based Analysis of DNA Methylation Patterns in Pediatric Acute Leukemia

    Author : Christofer Bäcklin; Mats Gustafsson; Markus Ringnér; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Recent evidence indicate that DNA methylation (DNAm) play a central role in the development and progression of the disease. READ MORE

  7. 20. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

    Author : Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

    Abstract : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. READ MORE