Search for dissertations about: "Mats Karlsson"
Showing result 1 - 5 of 106 swedish dissertations containing the words Mats Karlsson.
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1. Conduits in coronary artery bypass grafting surgery : Saphenous vein, radial and internal thoracic arteries
Abstract : A novel technique for saphenous vein (SV) graft harvesting, the No-touch technique (NT), has been developed at the Dept. of Cardiovascular surgery, Örebro University hospital. With NT the SV is harvested with a pedicle of surrounding tissue. This avoids graft spasm and eliminates the need for distension. READ MORE
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2. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials
Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE
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3. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination
Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE
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4. T lymphocytes in allergic rhinitis
Abstract : The role of the T lymphocyte and T cell associated events in the allergic reaction were investigated in the nasal mucosa and in the peripheral blood. Patients with seasonal allergic rhinitis (birch pollen) and healthy controls were subjected to an allergen provocation study during non-pollen season. READ MORE
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5. Novel methods for estimation of ligand binding kinetics and drug absorption
Abstract : .... READ MORE