Search for dissertations about: "Mats O. Karlsson"

Showing result 1 - 5 of 35 swedish dissertations containing the words Mats O. Karlsson.

  2. 1. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Author : Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE

  4. 2. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Author : Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE

  5. 3. Novel methods for estimation of ligand binding kinetics and drug absorption

    Author : Mats O. Karlsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 4. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis

    Author : Oskar Alskär; Maria C Kjellsson; Mats O Karlsson; Jenny Y. Chien; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; pharmacometrics; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. READ MORE

  7. 5. Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption

    Author : Martin Bergstrand; Mats O Karlsson; Hans Ericsson; Bart Ploeger; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Absorption; magnetic marker monitoring; drug release; IVIVC; pharmacometrics; NONMEM; model diagnostics; pcVPC; pvcVPC; visual predictive check; VPC; BQL; paracetamol; sulfapyridine.; Other pharmacy; Övrig farmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. READ MORE