Search for dissertations about: "Mattias Mannervik"

Showing result 6 - 10 of 14 swedish dissertations containing the words Mattias Mannervik.

  2. 6. Regulators of chromatin and transcription in Drosophila

    Author : Filip Crona; Mattias Mannervik; Fernando Azorin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transcription; chromatin; co-regulators; CBP; lysine demethylase; KDM4A; Brakeless; Drosophila; utvecklingsbiologi; Developmental Biology;

    Abstract : Development of multicellular organisms is achieved by organized temporal and spatial patterns of gene expression leading to cell differentiation. Chromatin regulators control how the DNA is utilized by altering access of proteins to DNA and thereby function as co-factors in transcription. READ MORE

  4. 7. Gene regulation during development by chromatin and the Super Elongation Complex

    Author : Olle Dahlberg; Mattias Mannervik; Peter Gergen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila development; gene regulation; transcription; chromatin; P-TEFb; Super Elongation Complex; KDM4A; H3K36me3; H3K14ac; histone replacement; utvecklingsbiologi; Developmental Biology;

    Abstract : Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. READ MORE

  5. 8. Chromatin regulators and transcriptional control of Drosophila development

    Author : Qi Dai; Mattias Mannervik; Albert J. Courey; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Co-factors; Transcription; Development; Drosophila; Developmental biology; Utvecklingsbiologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The development of a multicellular organism is programmed by complex patterns of gene expression. In eukaryotic cells, genes are packaged by histone proteins into chromatin. Chromatin regulators often function as transcription co-factors. READ MORE

  6. 9. The interplay of transcription and chromatin regulation during embryonic development

    Author : George Hunt; Mattias Mannervik; Eileen Furlong; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription; chromatin; chromatin-modifiers; p300 CBP; Polycomb repression; promoter proximal Pol II pausing; molekylär biovetenskap; Molecular Bioscience;

    Abstract : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. READ MORE

  7. 10. Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe

    Author : Anna Johnsson; Anthony Wright; Mattias Mannervik; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related events to occur, the chromatin needs to be modified by chromatin remodelling or, by reversible post-translational modifications. READ MORE