Search for dissertations about: "Mattias Sjöström"

Found 1 swedish dissertation containing the words Mattias Sjöström.

2. 1. Studies of leukotriene C4 synthase isoenzymes and the cysteinyl leukotrine receptors in human endothelial- and mast cells

   Author : Mattias Sjöström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Leukotriene (LT) C4, the parent compound of LTD4 and LTE4, is generated when LTA4 is conjugated with GSH by either leukotriene C4 synthase (LTC4S) or microsomal GSH S-transferase (MGST) type 2 or 3. Together these lipid mediators cause contractions particularly in airway smooth muscle and the microcirculation, leading to bronchconstriction, plasma extravasation and edema formation as well as increased mucus secretion from epithelial cells and recruitment of inflammatory cells. READ MORE