Search for dissertations about: "Measurable residual disease"
Showing result 1 - 5 of 6 swedish dissertations containing the words Measurable residual disease.
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1. Next Generation Sequencing for Measurable Residual Disease Detection in Acute Myeloid Leukemia
Abstract : Acute myeloid leukemia (AML) is the most common form of acute leukemia and generally associated with a poor prognosis. For both children and adults, the treatment is based on chemotherapy. Allogeneic hematopoietic stem cell transplant (alloHCT) is reserved for patients with intermediate or high risk of relapse, due to its associated risks. READ MORE
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2. Treatment failure in pediatric acute myeloid leukemia: factors associated with frequency and outcome of resistant disease and relapse
Abstract : Although the prognosis for childhood acute myeloid leukemia (AML) has improved over the last decades to a survival of over 70%, still 30-40 % relapse and 5-10% experience resistant disease with poor prognosis. The aim of this thesis was to perform a detailed analysis of disease characteristics and treatment in children with relapsed and resistant AML to provide means to improve prognosis. READ MORE
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3. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations
Abstract : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. READ MORE
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4. Liquid biopsies in pediatric oncology : towards clinical implementation
Abstract : During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies could serve many purposes in childhood oncology as well. READ MORE
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5. In Search of Prognostic Factors in Grade 2 Gliomas
Abstract : Grade 2 gliomas are malignant brain tumours affecting otherwise healthy adults. Although the long-term prognosis is poor, many patients are well and may have a high quality of life for several years. READ MORE