Search for dissertations about: "Mechanism of adaptation of hypoxia"

Showing result 1 - 5 of 9 swedish dissertations containing the words Mechanism of adaptation of hypoxia.

  2. 1. Mechanisms of activation of the hypoxia-inducible transcription factor 1a

    Author : Sallyann O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors HIF-1 alpha and HIF 1 beta/ARNT. Under hypoxic conditions HIF-1 becomes activated and transcriptionally upregulates a set of target genes involved in angiogenesis, erythropoesis and glycolysis. READ MORE

  4. 2. A molecular exploration of sensory responses in c. elegans

    Author : Longjun Pu; Changchun Chen; Simon Tuck; Sara I Wilson; Zhiyong Shao; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; C. elegans; sensation; CRISPR Cas9; G protein-coupled receptors; neuropeptides; acute hypoxia; pathogen; chemosensation; hydrogen sulfide; HIF-1; iron;

    Abstract : Sensation provides a pivotal ability, allowing animals to survive in complex environments. The cues sensed by animals are represented by external stimuli and internal signals. However, the mechanisms mediating sensations in molecular and cellular level are still not well-studied. In this thesis, by using free-living nematodes C. READ MORE

  5. 3. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Author : Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Abstract : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. READ MORE

  6. 4. Study of the mechanisms behind the additive effect of neoadjuvant castration on radiotherapy for prostate cancer

    Author : Firas L Tarish; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Castration improves responses to radiotherapy (RT) in prostate cancer with unknown mechanism. An understanding of what happens at the cellular and molecular level in prostate cancer cells, while reducing their access to androgens and then exposing them to ionizing radiation (IR), would give us an opportunity to optimize the treatment and may also inspire novel therapeutic approaches. READ MORE

  7. 5. Hypoxia-inducible factor-1 (HIF-1) in pancreatic cancer cell aggressiveness and therapeutic resistance and the potential role for pancreatic endocrine cells in islet transplantation

    Author : Xiaohui Jia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic functions in various tissues, including both normal and malignant. It is known that a heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) mainly mediates this critical adaptation. READ MORE