Search for dissertations about: "Mechanism-based"

Showing result 1 - 5 of 38 swedish dissertations containing the word Mechanism-based.

  1. 1. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anja Henningsson; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Mechanism-based; Modelling; Myelosuppression; Paclitaxel; Cremophor EL; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. READ MORE

  2. 2. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Petra Jauslin-Stetina; Uppsala universitet.; [2008]
    Keywords : Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. READ MORE

  3. 3. Mechanism-based flow stress model for Ti-6Al-4V applicable for simulation of additive manufacturing and machining

    University dissertation from Luleå : Luleå University of Technology

    Author : Bijish Babu; Luleå tekniska universitet.; [2018]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Material modeling; Ti-6Al-4V; dislocation density; vacancy concentration; additive manufacturing; hot forming; heat treatment; Material Mechanics; Materialmekanik;

    Abstract : Ti-6Al-4V has remarkable properties such as high specific mechanical properties (viz. stiffness, strength, toughness, fatigue resistance), corrosion resistance, biocompatibility etc. These properties make it attractive for applications in aerospace, chemical industry, energy production, surgical implants, etc. READ MORE

  4. 4. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bengt Hamrén; Uppsala universitet.; [2008]
    Keywords : Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

    Abstract : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population.Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. READ MORE

  5. 5. Mechanism-based modeling of biological processes involved in oral absorption

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Benjamin Guiastrennec; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; absorption; bile acids; enterohepatic circulation; food effect; gallbladder; in vitro in vivo correlation; NONMEM; pediatrics; pharmacometrics; tuberculosis; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. READ MORE