Search for dissertations about: "Medicin och hälsovetenskap Klinisk medicin Dermatologi och venereologi"

Showing result 16 - 20 of 176 swedish dissertations containing the words Medicin och hälsovetenskap Klinisk medicin Dermatologi och venereologi.

  2. 16. Skin Barrier Function and mRNA Expression Profiles in Patients with Atopic Dermatitis, Ichthyosis Vulgaris, and X-linked Recessive Ichthyosis : Aetiopathogenic Differences and the Impact of Moisturizing Treatment

    Author : Torborg Sturesdotter Hoppe; Berit Berne; Hans Törmä; Anders Vahlquist; Charlotta Enerbäck; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atopic dermatitis; ichthyosis vulgaris; X-linked recessive ichthyosis; skin barrier function; moisturizers; transepidermal water loss; gene expression; Dermatologi och venereologi; Dermatology and Venerology;

    Abstract : Atopic dermatitis (AD), ichthyosis vulgaris (IV), and X-linked recessive ichthyosis (XLRI) are characterized by dry skin and impaired skin barrier. AD and IV are related to loss-of-function mutations in FLG (encoding filaggrin), whereas XLRI is caused by deletions or inactivating mutations in the steroid sulphatase gene (STS). READ MORE

  4. 17. Congenital Recessive Ichthyosis : Studies of Gene Expressions Related to Keratinocyte Differentiation and Skin Barrier Repair

    Author : Hanqian Zhang; Hans Törmä; Anders Vahlquist; Marie Virtanen; Mikael Ivarsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genodermatoses; oligoarray; trancriptomics; transglutaminase-1; cornified envelope; peroxisome proliferator-activated receptor δ; all-trans retinoic acids.; Dermatologi och venereologi; Dermatology and Venerology;

    Abstract : Autosomal recessive congenital ichthyosis (ARCI) is a rare monogenetic disorder characterized by a defective skin barrier, hyperkeratosis, and dry, scaly skin. It affects keratinocyte differentiation and is caused by mutations in any of at least 12 genes believed to control the formation of ω-O-acylceramide and the corneocyte lipid envelope (CLE): ABCA12, ALOXE3, ALOX12B, CERS3, CYP4F22, ELOVL4, LIPN, NIPAL4, PNPLA1, SDR9C7, SLC27A4, and TGM1. READ MORE

  5. 18. CXCL16 and CD137 in atherosclerosis

    Author : Dick Wågsäter; Allan Sirsjö; Ewa Ehrenborg; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; atherosclerosis; chemokine; cytokine; endothelial cells; inflammation; low-density lipoprotein; macrophages; scavenger receptor; smooth muscle cells; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Abstract : Atherosclerosis is a progressive inflammatory disease that is characterized by the accumulation of lipids, infiltrated cells and fibrous elements in large arteries. This thesis focuses on the molecular mechanisms behind foam cell formation and inflammation, two central processes in the development of atherosclerosis. READ MORE

  6. 19. Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation

    Author : Peter Schmidt; Olle Korsgren; Bo Nilsson; Karin Ulrichs; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; xenotransplantation; islets of Langerhans; rejection; diabetes; porcine endogenous retroviruses; quantitative RT-PCR; cytokines; animal models; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : In the field of transplantation, the increasing deficit of human donors have lead to an interest in animals as an alternative source of organs and tissues. Different in vitro systems and rodent models of xenotransplantation were used to examine the most significant barriers that have to be overcome, before isolated islets of Langerhans from pigs can be used as a cure for insulin-dependent diabetes mellitus in humans. READ MORE

  7. 20. Lipids and Endothelium-Dependent Vasodilation

    Author : Peter Steer; Lars Lind; Per Tornvall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Atherosclerosis; endothelium; vasodilation; nitric oxide; fatty acid; meal; diet; lipoprotein; cyclooxygenase; diclophenac; L-arginine; LDL; human; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Internal Medicine; Internmedicin;

    Abstract : Impaired endothelium-dependent vasodilation (EDV) is associated with atherosclerotic cardiovascular disease as well as several of its risk factors. The aim of the present thesis was to investigate how lipids influence EDV in the vascular bed of the human forearm. READ MORE