Search for dissertations about: "Medicinsk mikrobiologi"

Showing result 11 - 15 of 427 swedish dissertations containing the words Medicinsk mikrobiologi.

  2. 11. Functional characterization of the human adenovirus pVII protein and non-coding VA RNAI

    Author : Raviteja Inturi; Tanel Punga; Goran Akusjarvi; Thomas Dobner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; VA RNA; protein VII; Ubiquitination; proteasome; anti-viral; Medical Biochemistry; Medicinsk biokemi; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Abstract : Human adenovirus (HAdV) is a common pathogen causing a broad spectrum of diseases. HAdV encodes the pVII protein, which is involved in nuclear delivery, protection and expression of viral DNA. To suppress the cellular interferon (IFN) and RNA interference (RNAi) systems, HAdVs encode non-coding virus-associated (VA) RNAs. READ MORE

  4. 12. Evolution and host-specific adaptations of Legionella pneumophila

    Author : Anaísa B. Moreno; Lionel Guy; Dan I. Andersson; Fredrik Söderbom; Alexander W. Ensminger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Evolution; Legionella pneumophila; host-adaptation; experimental evolution; Acanthamoeba castellanii; transfection; Mikrobiologi; Microbiology;

    Abstract : How bacteria evolve pathogenic traits is shaped by their communities and environments. Legionella pneumophila is ubiquitous in aquatic habitats, where it persists by replicating within a broad range of protozoan hosts. Using the same mechanisms, L. READ MORE

  5. 13. Construction of Adenovirus Vectors for Studies of Protein Function and RNA Interference

    Author : Saideh Berenjian; Göran Akusjärvi; Mikael Berg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Adenovirus; viral vectors; VA RNAI II; RNAi; Tet-ON OFF; RNA splicing; Mikrobiologi; Microbiology; Mikrobiologi;

    Abstract : During an adenovirus infection the accumulation of alternatively spliced mRNAs is subjected to a tight temporal regulation. The IIIa protein is a structural protein expressed exclusively late after infection. READ MORE

  6. 14. Biased Evolution : Causes and Consequences

    Author : Gerrit Brandis; Diarmaid Hughes; Erik Böttger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolution; Codon usage bias; Post-transcriptional regulation; Recombination; Inversion; EF-Tu; Frameshift suppression; Antibiotic resistance; Rifampicin; Ciprofloxacin; Compensatory evolution; Drug efflux; RNA polymerase; DNA gyrase; Mikrobiologi; Microbiology;

    Abstract : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. READ MORE

  7. 15. Exploring the Ciprofloxacin Resistome

    Author : Linnéa Garoff; Diarmaid Hughes; Jesús Blázquez; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Experimental evolution; Ciprofloxacin; Escherichia coli; Mikrobiologi; Microbiology;

    Abstract : This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug target binding, increasing drug efflux, and modifying the drug. READ MORE