Search for dissertations about: "Medicinsk proteinvetenskap"

Showing result 1 - 5 of 15 swedish dissertations containing the words Medicinsk proteinvetenskap.

  2. 1. Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum

    Author : Kimi Drobin; Jochen M. Schwenk; Peter Nilsson; Ulrika Qundos; Angela Silveira; Maria Pernemalm; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; plasma; serum; biomarker discovery; osteoporosis; inflammatory bowel disease; Crohn s disease; ulcerative colitis; Medical Technology; Medicinsk teknologi;

    Abstract : Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. READ MORE

  4. 2. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy

    Author : Charles Dahlsson Leitao; Stefan Ståhl; John Löfblom; Christoph Rader; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; radionuclide imaging; affibody molecules; HER-receptors; prodrug; protein design; Cancerterapi; radionuklidavbildning; affibody molekyler; HER-receptorer; prodrog; proteindesign; Bioteknologi; Biotechnology;

    Abstract : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. READ MORE

  5. 3. Bifunctional ADAPTs: Opportunity for serological Half-life extension and Targeted therapy

    Author : Andreas Wisniewski; Sophia Hober; Masood Kamali-Moghaddam; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Autoimmune diseases; Cancer; Half-life extension; HRP; Phage Display; Protein Engineering; Targeted therapy; Biotechnology; Bioteknologi;

    Abstract : Small engineered scaffold proteins (ESPs) gain more and more popularity as biological drugs, due to their specificity and applicability in diagnostics and therapy. Thanks to their high stability, low immunogenicity and low production cost, they present themselves as a promising alternative to the market-leading antibodies. READ MORE

  6. 4. Finding order in chaos : Dissecting single-cell heterogeneity in space and time

    Author : Christian Gnann; Emma Lundberg; Manuel D Leonetti; Lucas Pelkmans; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-genetic single-cell heterogeneity; cell cycle; metabolism; imaging-based subcellular proteomics; phosphoproteomics; icke-genetisk single-cell heterogenitet; cellcykel; metabolism; bildbaserad subcellulär proteomik; fosfoproteomik; Biotechnology; Bioteknologi;

    Abstract : The cell is the smallest unit of life and contains DNA, RNA, proteins and a variety of other macromolecules. In recent years, technological advances in the field of single cell biology have revealed a staggering amount of phenotypic heterogeneity between cells in a population, which were previously considered homogenous. READ MORE

  7. 5. Strategies to improve and balance the expression levels of recombinant proteins in mammalian cell lines

    Author : Mona Moradi Barzadd; Johan Rockberg; Alan Dickson; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CHO; HEK293; Aggregation; Bispecific; Cancer assay; Cell line engineering; sulfatase; biologics; transcriptomic; Biotechnology; Bioteknologi;

    Abstract : Proteins are the building blocks of all living organisms enabling us to function and survive. There are more than 100,000 different proteins in the human body performing a variety of vital tasks. READ MORE