Search for dissertations about: "Medulloblastoma"

Showing result 1 - 5 of 32 swedish dissertations containing the word Medulloblastoma.

  1. 1. The Role of SOX9 in Medulloblastoma

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Vasil Savov; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; SOX9; MYCN; cancer development; recurrence; regulation; tumor metastasis; migration; Medical Science; Medicinsk vetenskap;

    Abstract : Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Overall survival is about 70% and in cases where current treatment fails, the disease recurs and most often is fatal. At the molecular level, MB can be divided into four defined subgroups: WNT, SHH, Group 3 and Group 4. READ MORE

  2. 2. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Bolin; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Recurrence; MYC; SOX9; FBW7; Treatment; BET bromodomains; Cyclin-dependent kinases; Oncology; Onkologi;

    Abstract : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. READ MORE

  3. 3. From Genes to Therapy Modeling and Novel Therapeutic Strategies for Brain Tumors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Matko Čančer; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Glioblastoma; MYCN; PDGF; Cancer Therapy; BET bromodomains; Temozolomide; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

    Abstract : Medulloblastoma is the most common malignant pediatric brain tumor and is molecularly divided into four subgroups – WNT, SHH, Group 3 and Group 4. Two thirds of medulloblastoma patients survive, but survivors often suffer from severe, lifelong side-effects. The MYCN oncogene is deregulated in many medulloblastoma patients. READ MORE

  4. 4. PDGF in cerebellar development and tumorigenesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johanna Andræ; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cerebellum; medulloblastoma; PDGF; GFAP; transgenic mice; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Abstract : Medulloblastoma is a highly malignant cerebellar childhood tumor. As in many other brain tumors, expression of platelet-derived growth factor (PDGF) and its receptors has been shown in medulloblastoma. READ MORE

  5. 5. Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications

    University dissertation from Lund University, Faculty of Medicine

    Author : Emma Sandén; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric Brain Tumor; Experimental model; Immunotherapy; Immune monitoring; Medulloblastoma;

    Abstract : Brain tumors are the most common solid tumors in children. Current treatment protocols fail in 25% of patients and are associated with significant long-term adverse effects in survivors. READ MORE