Search for dissertations about: "Melanocortin 1 Receptor"

Showing result 1 - 5 of 16 swedish dissertations containing the words Melanocortin 1 Receptor.

2. 1. Podocyte Melanocortin 1 Receptor Mediated Signaling : A potential new target for patients with kidney diseases

   Author : Johannes Elvin; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Podocyte; Melanocortin 1 Receptor; actin cytoskeleton; nephrotic syndrome; adrenocorticotropic hormone; oxidative stress; RhoA; Kidney disease;

   Abstract : Treatment of patients with nephrotic syndrome (NS) is currently unspecific and directed at ameliorating the symptoms rather than eliminating the cause. NS is actually a multitude of glomerular diseases characterized by poorly understood disease mechanisms and symptoms that include proteinuria, hypoalbuminemia and edema. READ MORE

4. 2. Mutational analysis of melanocortin receptors 1 and 5

   Author : Per-Anders Frändberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Melanocortin receptor; melanocortin peptide; MSH; NDP-MSH; mutagenesis human phenotype; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

   Abstract : The melanocortin receptor family includes five subtypes, named MC1R to MC5R. Melanocortin receptors are predominantly coupled to second messenger pathway of cyclic AMP through coupling to G-protein. This study is focused on structure-function relationship of MC1R and MC5R. READ MORE

5. 3. The role of melanocortin 1 receptor in kidney disease

   Author : Annika Lindskog Jonsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephrotic syndrome; proteinuria; adrenocorticotropic hormone; melanocortin 1 receptor; podocytes;

   Abstract : Nephrotic syndrome is a term describing a group of poorly understood glomerular diseases that are responsible for a steadily increasing number of patients requiring active uremic care. Characteristic symptoms of nephrotic syndrome are proteinuria, hypoalbuminemia, hyperlipidemia and peripheral edema, and treatment of these symptoms, rather than their cause, is currently the only option available to the clinician. READ MORE

6. 4. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

   Author : Viveka Dolby; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

   Abstract : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. READ MORE

7. 5. Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1

   Author : Åke Västermark; Helgi Schiöth; Arne Elofsson; Uppsala universitet; []
   Keywords : ;

   Abstract : Integral membrane proteins play a key role hormonal and neuronal signaling. Transmembrane helix (TM) proteins form about 27% of the human proteome. Furthermore, 44% of the human drug targets are receptors, and 19% of these are seven-transmembrane domain receptors (GPCRs), which constitute 4% of the entire protein-coding genome. READ MORE