Search for dissertations about: "Melanocortin receptor 4"

Showing result 1 - 5 of 10 swedish dissertations containing the words Melanocortin receptor 4.

2. 1. Cloning, Expression, Pharmacological Characterization and Anatomical Distribution of Melanocortin Receptors in an Evolutionary Perspective

   Author : Aneta I. Ringholm; Helgi B. Schiöth; Dan Larhammar; Björn Olde; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; evolution; melanocortin; MSH; pharmacology; genome duplication; tetraploidization; zebrafish; spiny dogfish; chicken; GPCR; polymorphism; pigmentation; Farmakologi; Pharmacological research; Farmakologisk forskning;

   Abstract : The melanocortin (MC) receptors are G-protein coupled receptors thatparticipate in several important physiological functions such as the regulation of the energy balance. This thesis focuses on the evolutionary aspect of the MC receptors and their pharmacology.One MC4 receptor and two MC5 receptor subtypes were found in a teleost fish, zebrafish. READ MORE

4. 2. Molecular Mechanisms of Reward and Aversion

   Author : Anna Klawonn; David Engblom; Anders Blomqvist; Paul Kenny; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motivation; Dopamine; Reward; Aversion; Negative affect; Systemic Inflammation; Drug Addiction; Cytokines; Prostaglandin E2; Melanocortin receptor 4; Acetylcholine; Muscarinic M4 receptor;

   Abstract : Various molecular pathways in the brain shape our understanding of good and bad, as well as our motivation to seek and avoid such stimuli. This work evolves around how systemic inflammation causes aversion; and why general unpleasant states such as sickness, stress, pain and nausea are encoded by our brain as undesirable; and contrary to these questions, how drugs of abuse can subjugate the motivational neurocircuitry of the brain. READ MORE

5. 3. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

   Author : Viveka Dolby; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

   Abstract : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. READ MORE

6. 4. Neurotrophic Factor Receptors in the Normal and Injured Visual System : Focus on Retinal Ganglion Cells

   Author : Niclas Lindqvist; Finn Hallböök; Anders Kvanta; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; cell survival; gene expression; neurotrophic factor; receptor; retina; visual system; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

   Abstract : The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. READ MORE

7. 5. Brain Stem Involvement in Immune and Aversive Challenge

   Author : Jakob Paues; Anders Blomqvist; Finn Hallböök; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipopolysaccharide; Lithium Chloride; anorexia; aversion; parabrachial; brain stem; melanocortin; CGRP; enkephalin; Neurobiology; Neurobiologi;

   Abstract : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. READ MORE