Search for dissertations about: "Melanoma"

Showing result 6 - 10 of 297 swedish dissertations containing the word Melanoma.

  2. 6. Genomic analysis of primary and metastatic malignant melanoma

    Author : Katja Harbst; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; next-generation sequencing; microarray; progression; molecular grade; subtype; melanoma;

    Abstract : “Cutaneous melanoma is a most unpredictable lesion” wrote Alexander Breslow in 1970. He was one of the first to predict outcome in melanoma patients, based on the thickness of the primary tumor, and today this parameter bears his name and remains the main prognostic factor in melanoma. READ MORE

  4. 7. The Role of Melanocyte Lineage Genes in Melanoma

    Author : Adriana Sanna; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Genetic; Epigenetic; Heterogeneity; MITF; SOX10; CSD;

    Abstract : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. READ MORE

  5. 8. Development of individualized surgical treatments for malignant melanoma

    Author : Valerio Belgrano; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; sentinel node; isolated limb perfusion; immune-humanized xenograft mouse models; translational research;

    Abstract : Background: Cutaneous melanoma is a malignancy with an increasing incidence worldwide, especially in northern Europe. The aim of this thesis is to scrutinize the results achieved by traditional surgery and the opportunities offered by translational research for the more advanced stages of the disease. READ MORE

  6. 9. Clinical aspects of molecular profiles in metastatic malignant melanoma

    Author : Henrik Ekedahl; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanom; Prognos; BRAF; TERT; Genuttryck; Next generation sequencing; Melanoma; Prognosis; BRAF; TERT; Gene Expression; Next generation sequencing;

    Abstract : Malignant melanoma is a heterogeneous, malignant neoplastic disease, most often originating in the skin. Melanoma is characterized by a high mutational load and has a vastly variable prognosis, depending on disease stage. READ MORE

  7. 10. Immunological effects of isolated regional perfusion in malignant melanoma

    Author : Junko Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Isolated regional perfusion; ILP; IHP; Melphalan; Immunogenic cell death; T cells; Monocytes; ISG;

    Abstract : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. READ MORE