Search for dissertations about: "Melphalan"

Showing result 1 - 5 of 17 swedish dissertations containing the word Melphalan.

  2. 1. Preclinical Studies of the Melphalan Prodrug J1 for Cancer Therapy

    Author : Malin Wickström; Joachim Gullbo; Rolf Larsson; Johan Hansson; Uppsala universitet; []
    Keywords : Pharmacology; Pharmacology; Chemotherapy; Melphalan prodrug; Cancer; Farmakologi;

    Abstract : J1 (L-melphalanyl-L-p-fluorophenylalanyl ethyl ester) is a dipeptide derivative of the alkylating agent melphalan with increased cytotoxicity. In this thesis the preclinical pharmacology of J1 has been characterized.Our results show that J1 rapidly enters the cells, where melphalan is released by hydrolysis. READ MORE

  4. 2. Pathogenesis and treatment of chemical-induced lung injury

    Author : Elisabeth Wigenstam; Anders Bucht; Thomas Sandström; Kjell Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemical-induced lung injury; dexamethasone; melphalan; vitamin E; respiratory mechanics; lungmedicin; Lung Medicine;

    Abstract : Inhalation of chemical substances can cause irritation to airways and in high doses acute airway injury. When mice are exposed to the alkylating nitrogen mustard analogue melphalan they develop an acute airway inflammation with a rapid influx of neutrophils to the lungs. READ MORE

  5. 3. Immunological effects of isolated regional perfusion in malignant melanoma

    Author : Junko Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Isolated regional perfusion; ILP; IHP; Melphalan; Immunogenic cell death; T cells; Monocytes; ISG;

    Abstract : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. READ MORE

  6. 4. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy

    Author : Joachim Gullbo; Rolf Larsson; Peter Nygren; Staffan Eriksson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; pharmacology; oncology; chemistry; Melphalan derivatives; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE

  7. 5. AL amyloidosis : Study of epidemiology, diagnosis and treatment with emphasis on heart involvement

    Author : Sara Rosengren; Kristina Carlson; Jens Sörensen; Stefan Schönland; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin light chain AL amyloidosis; high-dose melphalan; cardiac amyloidosis; positron emission tomography PET ; incidence; population-based; Medicinsk vetenskap; Medical Science;

    Abstract : AL (immunoglobulin light chain) amyloidosis is often associated with delayed diagnosis and thereby high early mortality that is not overcome by contemporary treatment. There is a need for diagnostic methods promoting earlier diagnosis, especially in patients with cardiac involvement. READ MORE