Search for dissertations about: "Merkel cell carcinoma"

Showing result 1 - 5 of 9 swedish dissertations containing the words Merkel cell carcinoma.

  2. 1. Epidemiology, diagnostics and treatment of non-melanoma skin cancers

    Author : Oscar Zaar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; non-melanoma skin cancer; basal cell carcinoma; merkel cell carcinoma; Bowen’s disease; imaging mass spectrometry; lipidomics; photodynamic therapy;

    Abstract : Skin cancer, including malignant melanoma and non-melanoma skin cancer (NMSC), is a growing problem due to the increasing incidence in Sweden and in other Caucasian populations. NMSCs are diagnosed as often as all other cancers combined and include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), precursors to SCC such as Bowen’s disease (BD) and actinic keratosis (AK), as well as several rare skin cancers including Merkel cell carcinoma (MCC). READ MORE

  4. 2. Dissecting the roles of viral T-antigens in Merkel cell carcinoma

    Author : Jiwei Gao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced DNA damage. The MCPyV T-antigens are major drivers for MCC oncogenesis. READ MORE

  5. 3. Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma

    Author : Satendra Kumar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of truncated LT. It is evident that the viral truncated LT and small T antigen (sT) play important roles in MCC tumorigenesis. READ MORE

  6. 4. Studies on polyomaviruses in humans : in relation to haematopoietic stem cell transplantation and cancer

    Author : Géraldine Giraud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The simultaneous discovery of two polyomaviruses in humans in 1971, BK and JC viruses (BKV and JCV), initiated the research on polyomaviruses in relation to human diseases. This has now been intensified with the consecutive discoveries, the last three years, of three new family members, KI, WU and Merkel cell polyomaviruses (KIPyV, WUPyV and MCPyV). READ MORE

  7. 5. Endocrine tumour development : with special focus on chromosome arms 1p and 11q

    Author : Brita Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endocrine tumour; Follicular thyroid tumour; Malignant melanoma; Midgut carcinoid; Pheochromocytoma; Abdominal paraganglioma; Merkel cell carcinoma; MEN1; SDHD; RIZ;

    Abstract : The overall goal of this thesis has been to characterise the involvement of chromosome arms 1p and 11 q in the development of endocrine tumours. The MEN1 gene was analysed as a candidate tumour suppressor gene by screening for mutations in follicular thyroid tumours, malignant melanomas, pheochromocytomas, and abdominal paragangliomas. READ MORE