Search for dissertations about: "Mesencephalic"

Showing result 1 - 5 of 37 swedish dissertations containing the word Mesencephalic.

  2. 1. Mechanisms and time course of cell death in embryonic nigral tissue and intrastriatal transplants

    Author : Mia Emgård; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothermia; resveratrol; free radicals; ultrastructure; electron microscopy; mesencephalic; transplantation; rat; Parkinson s disease; dopamine; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and severely affects about one in a hundred persons over the age of fifty years. In PD, there is a reduced striatal concentration of the neurotransmittor dopamine, mainly caused by a degeneration of the dopaminergic neurons in the substantia nigra. READ MORE

  4. 2. Subsystems of the basal ganglia and motor infrastructure

    Author : Iman Kamali Sarvestani; Örjan Ekeberg; Jeanette Hällgren-Kotaleski; Christelle Baunez; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Basal Ganglia; Action Selection; Motor Learning; Tectum; Superior Colliculus; Mesencephalic Locomotor Region; Reticulospinal Neurons; Computational Models;

    Abstract : The motor nervous system is one of the main systems of the body and is our principle means ofbehavior. Some of the most debilitating and wide spread disorders are motor systempathologies. In particular the basal ganglia are complex networks of the brain that control someaspects of movement in all vertebrates. READ MORE

  5. 3. Intracranial and intraocular grafting of fetal ventral mesencephalic and striatal tissues : neuronal survival and nerve growth characteristics

    Author : Lars Björklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parkinson s disease; grafting; ventral mesencephalon; striatum; dopamine; innervation; growth pattem; GDNF; U-74006F;

    Abstract : Parkinson's disease is caused by degeneration of dopaminergic neurons in the ventral mesencephalon. Various animal models and clinical trials has shown that grafts of fetal ventral mesencephalic tissue can survive and functionally reinnervate the dopamine-depleted striatum, leading to long-term improvements of therapeutic value, but still symptomatic relief is far from complete. READ MORE

  6. 4. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

    Author : Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

    Abstract : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. READ MORE

  7. 5. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

    Author : Gabriele Schierle; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ac-YVAD-cmk; MK-801; flunarizine; N-methyl-D-aspartate; voltage-dependent calcium channels; Bcl-2; caspase; excitotoxicity; apoptosis; tyrosine hydroxylase; dopamine; Parkinson s disease; intracerebral transplantation; Poly ADP-ribose polymerase; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. READ MORE