Search for dissertations about: "Mesoderm"

Showing result 1 - 5 of 32 swedish dissertations containing the word Mesoderm.

  2. 1. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

    Author : Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
    Keywords : Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

    Abstract : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. READ MORE

  4. 2. The Role of the SHB Adapter Protein in Cell Differentiation and Development

    Author : Vitezslav Kriz; Michael Welsh; Urban Lendahl; Uppsala universitet; []
    Keywords : Cell biology; SHB; transgene; ES cells; cavitation; knockout; mouse; vasculogenesis; hematopoiesis; endoderm; mesoderm; malformation; Cellbiologi;

    Abstract : The present study was conducted in order to assess a role of the SH2 domain-containing adapter protein SHB in development and cell differentiation.Embryonic stem (ES) cells overexpressing SHB and SHB with an inactive SH2 domain (R522K-SHB) were obtained. READ MORE

  5. 3. Developmental origin and molecular regulation of vascular smooth muscle cells

    Author : Per Wasteson; Göteborgs universitet; []
    Keywords : smooth muscle cell; aorta; cell origin; lateral plate mesoderm; paraxial mesoderm; lipoma preferred partner; serum response factor; neointimal hyperplasia; angiotensin II; platelet-derived growth factor-B;

    Abstract : Several pathologies of the vascular system have been suggested to be dependent on the smooth muscle cells (SMCs) that build up the vessel wall. Aortic SMCs have been proposed to derive from lateral plate mesoderm. READ MORE

  6. 4. Midgut and muscle development in Drosophila melanogaster

    Author : Margret Shirinian; Ruth Palmer; Anne Uve; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; visceral mesoderm; endoderm; somatic muscles; Alk; C3G; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The fully developed and functional Drosophila midgut comprises two layers, the visceral mesoderm and the endoderm. The visceral muscle of the midgut is formed by the fusion of founder cells with fusion competent cells to form the muscle syncytia. READ MORE

  7. 5. Deciphering the Alk signaling pathway in Drosophila

    Author : Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

    Abstract : In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. READ MORE