Search for dissertations about: "Metabolic Fingerprinting"

Found 3 swedish dissertations containing the words Metabolic Fingerprinting.

  2. 1. Analysis of Metabolites in Complex Biological Samples Using LC/MS and Multivariate Data Analysis : Metabolic Fingerprinting and Detection of Biomarkers

    Author : Helena Idborg; Sven Jacobsson; Per-Olof Edlund; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Metabonomics; Metabolic Fingerprinting; Drug Metabolism; Biomarkers; Human Plasma; Rat Urine; LC MS; ZIC-HILIC; UPLC; UHPLC; ToF; Curve Resolution; Peak Detection; Pattern Recognition; Classification; PCA; PLS; PARAFAC; N-PLS; Data Fusion; Hierarchical Modeling; Batch modeling; Data Concatenation; Breast Cancer; Phospholipidosis; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : To facilitate early diagnosis of diseases and elucidation of the processes involved in their development and progression, various specific compounds or ‘biomarkers’ are often monitored. The first step is to decide which compounds to analyze. READ MORE

  4. 2. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

    Author : Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. READ MORE

  5. 3. Sample preparation and mass spectrometry in proteome studies

    Author : Daniel Hirschberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proteome studies aim to link gene to function. Instead of screening for function in a specific protein as in classical protein chemistry, proteins are now screened against a specific phenotype, disease or metabolic state. READ MORE