Search for dissertations about: "Metabolic analysis"

Showing result 1 - 5 of 541 swedish dissertations containing the words Metabolic analysis.

  2. 1. Metabolic analysis of shikimic acid producing Escherichia coli

    Author : Louise Johansson; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; Biokemi; metabolism; Chemical technology and engineering; transcriptome analysis; phosphorus-limitation; carbon-limitation; fed-batch; chemostat; batch; fermentation technology; Escherichia coli; shikimic acid; Biotechnology; Bioteknik; Metabolism; Biochemistry; principal component analysis; 2D-fluorescence spectrophotometry; metabolic flux analysis; carbon-rich;

    Abstract : Shikimic acid production using recombinant E.coli has been developed during the past 15 years due to the increased demand of this product, primarily as a starting material for the anti-influensa medicine Tamiflu?. A detailed metabolic analysis of a shikimic acid producing E. READ MORE

  4. 2. Processing and analysis of NMR data : Impurity determination and metabolic profiling

    Author : Jenny Forshed; Sven P. Jacobsson; Jules L. Griffin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; quantitative nuclear magnetic resonance spectrometry; qNMR; multivariate analysis; peak alignment; data fusion; Analytical chemistry; Analytisk kemi;

    Abstract : This thesis describes the use of nuclear magnetic resonance (NMR) spectrometry as an analytical tool. The theory of NMR spectroscopy in general and quantitative NMR spectrometry (qNMR) in particular is described and the instrumental properties and parameter setups for qNMR measurements are discussed. READ MORE

  5. 3. Analysis of Metabolites in Complex Biological Samples Using LC/MS and Multivariate Data Analysis : Metabolic Fingerprinting and Detection of Biomarkers

    Author : Helena Idborg; Sven Jacobsson; Per-Olof Edlund; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Metabonomics; Metabolic Fingerprinting; Drug Metabolism; Biomarkers; Human Plasma; Rat Urine; LC MS; ZIC-HILIC; UPLC; UHPLC; ToF; Curve Resolution; Peak Detection; Pattern Recognition; Classification; PCA; PLS; PARAFAC; N-PLS; Data Fusion; Hierarchical Modeling; Batch modeling; Data Concatenation; Breast Cancer; Phospholipidosis; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : To facilitate early diagnosis of diseases and elucidation of the processes involved in their development and progression, various specific compounds or ‘biomarkers’ are often monitored. The first step is to decide which compounds to analyze. READ MORE

  6. 4. Metabolic variation in autoimmune diseases

    Author : Rasmus Kirkegaard Madsen; Johan Trygg; Thomas Moritz; Torbjörn Lundstedt; Matej Oresic; Umeå universitet; []
    Keywords : Rheumatoid Arthritis; Diabetes Mellitus type 1; Metabolic Profiling; Metabolomics; Chemometrics; Multivariate Data Analysis; Mass Spectrometry; biologisk kemi; biological chemistry;

    Abstract : The human being and other animals contain immensely complex biochemical processes that govern their function on a cellular level. It is estimated that several thousand small molecules (metabolites) are produced by various biochemical pathways in humans. READ MORE

  7. 5. On metabolic networks and multi-omics integration

    Author : Rasmus Ågren; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

    Abstract : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. READ MORE