Search for dissertations about: "Metabolic modelling"

Showing result 21 - 25 of 42 swedish dissertations containing the words Metabolic modelling.

  2. 21. Modelling of steatosis and insulin resistance development in human hepatic 3d spheroids : mechanisms and genetic aspects

    Author : Mikael Kozyra; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hepatic steatosis and insulin resistance are common disease manifestations seen in metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) patients. Aberrant hepatic lipid accumulation leads to both morphological changes and metabolic alterations in liver function and may cause serious end-stage liver disease. READ MORE

  4. 22. Molecular mechanisms involved in prokaryotic cycling of labile dissolved organic matter in the sea

    Author : Benjamin Pontiller; Jarone Pinhassi; Daniel Lundin; Catherine Legrand; Martin F. Polz; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bacteria and archaea; labile dissolved organic matter; metatranscriptomics; monomers; polymers; carbohydrate-active enzymes CAZymes ; peptidases; membrane transporters; Natural Science; Naturvetenskap; Akvatisk ekologi; Aquatic Ecology; Mikrobiologi; Microbiology;

    Abstract : Roughly half of the global primary production originates from microscopic phytoplankton in marine ecosystems, converting carbon dioxide into organic matter. This organic matter pool consists of a myriad of compounds that fuel heterotrophic bacterioplankton. READ MORE

  5. 23. Multivariate data analysis of metabolomic multi-tissue samples

    Author : Frida Torell; Johan Trygg; Torbjörn Lundstedt; Thomas Moritz; Kate Bennett; Michal Daszykowski; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Multi-tissue metabolomics involves characterisation of the metabolome of several tissue types. The metabolome consists of small chemical entities of low molecular weight called metabolites, which are constantly produced and interchanged through a vast variety of biochemical reactions occurring throughout living organisms. READ MORE

  6. 24. Systems-level investigation of the interaction between glucose metabolism and the Snf1/Mig1 signalling pathway

    Author : Niek Welkenhuysen; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glucose signalling; microfluidics; Saccharomyces cerevisiae;

    Abstract : Saccharomyces cerevisiae Snf1 and its mammalian homolog, AMPK, are members of a protein kinase family present throughout the Eukaryotic kingdom. AMPK plays an essential role in different cellular processes and is involved in diseases such as diabetes, obesity and cancer. READ MORE

  7. 25. Effects of burns and vasoactive drugs on human skin : Clinical and Experimental studies using microdialysis

    Author : Anders Samuelsson; Folke Sjöberg; Ola Winsö; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Patients who require critical care, including those with burns, are affected by a systemic inflammatory reaction, which at times has consequences such as multiple organ dysfunction and failure. It has become increasingly evident that other factors important in the development of organ dysfunction are disturbances at the tissue level, in the microcirculation. READ MORE