Search for dissertations about: "Metabolic network"

Showing result 1 - 5 of 102 swedish dissertations containing the words Metabolic network.

  2. 1. On metabolic networks and multi-omics integration

    Author : Rasmus Ågren; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

    Abstract : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. READ MORE

  4. 2. Macroscopic models of Chinese hamster ovary cell cultures

    Author : Erika Hagrot; Véronique Chotteau; Anders Forsgren; Nathan E. Lewis; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary; Amino acid; Metabolic network; Metabolic flux analysis; Kinetic modeling; Elementary flux mode; Optimization; Column generation; Bioteknologi; Biotechnology;

    Abstract : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. READ MORE

  5. 3. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration

    Author : Saeed Shoaie; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; meta’omics; complexity; obesity; network topology; Gut microbiome; genome-scale metabolic model; gene richness; CASINO; systems biology; flux balance analysis; diabetes;

    Abstract : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. READ MORE

  6. 4. Metabolic Engineering of Saccharomyces cerevisiae for Sesquiterpene Production

    Author : Gionata Scalcinati; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Systems Biology; Saccharomyces cerevisiae.; Evolutionary engineering; Metabolic Engineering; Microrefinery; Cell factory; Synthetic Biology;

    Abstract : Industrial biotechnology aims to develop robust “microbial cell factories”, to produce an array of added value chemicals presently dominated by petrochemical processes. The exploitation of an efficient microbial production as sustainable technology has an important impact for our society. READ MORE

  7. 5. Systems and Network-based Approaches to Complex Metabolic Diseases

    Author : Muhammad Arif; Adil Mardinoglu; Thomas Sauter; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioteknologi; Biotechnology;

    Abstract : The future of healthcare is personalized medicine, in which disease treatments are tailored based on the individual characteristics of each patient. To reach that objective, we need to obtain a better understanding of diseases. READ MORE