Search for dissertations about: "Mevalonate pathway"

Showing result 1 - 5 of 26 swedish dissertations containing the words Mevalonate pathway.

  2. 1. Mevalonate pathway end-products : metabolism, utilization and regulation

    Author : Anders Thelin; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  4. 2. Inhibition of the mevalonate pathway in C. elegans: Consequences and implications

    Author : Parmida Ranji; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mevalonate pathway; C. elegans; atfs-1; mitochondrial unfolded response UPR ;

    Abstract : The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on the mevalonate pathway using C. READ MORE

  5. 3. Following the mevalonate pathway to bone heal alley

    Author : Björn Skoglund; Lars Nordsletten; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Bone screws; coated materials; biocompatible; chemistry; diphosphonates; pharmacology; Equipment failure analysis methods; Femoral fractures; drug therapy; fracture fixation; instrumentation; Fracture fixation; fracture healing; drug effects; simvastatin; tibial fractures; physiopathologyial fractures; surgery; Pharmaceutical chemistry; Farmaceutisk kemi; Other veterinary medicine; Övrig veterinärmedicin;

    Abstract : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. READ MORE

  6. 4. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Author : Siavash Partow; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Abstract : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. READ MORE

  7. 5. Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis

    Author : Lena M Henriksson; Torsten Unge; Sherry L. Mowbray; Barbara Seaton; Uppsala universitet; []
    Keywords : Molecular biology; Mycobacterium tuberculosis; Rv0009; peptidyl-prolyl cis-trans isomerase; Rv2870c; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; non-mevalonate pathway; DOXP MEP pathway; X-ray crystallography; Molekylärbiologi;

    Abstract : Mycobacterium tuberculosis, the causative pathogen of tuberculosis, currently infects one-third of the world’s population, resulting in two million deaths annually. This clearly shows that tuberculosis is one of the most serious diseases of our times. READ MORE