Search for dissertations about: "Michael C. Zody"

Found 2 swedish dissertations containing the words Michael C. Zody.

  2. 1. Investigation of Mechanics of Mutation and Selection by Comparative Sequencing

    Author : Michael C. Zody; Kerstin Lindblad-Toh; Leif Andersson; Chad Nusbaum; Henrik Kaessmann; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chicken; chimpanzee; human; evolution; segmental duplication; structural variation; chromosomal rearrangement; comparative genomics; positive selection; selective sweep; Genetics; Genetik; Genetics; genetik;

    Abstract : The process of evolution is of both scientific and medical interest. This thesis presents several studies using complete genomic reference sequences, comparative genomic data, and intraspecific diversity data to study the two key processes of evolution: mutation and selection. READ MORE

  4. 2. Genetic Cartography at Massively Parallel Scale

    Author : Johan Dahlberg; Ann-Christine Syvänen; Adam Ameur; Michael C. Zody; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia ALL ; RNA-Sequencing; Bioinformatics; Pooling; Whole Genome Sequencing; Medicinsk genetik; Medical Genetics; Bioinformatics; Bioinformatik;

    Abstract : Massively parallel sequencing (MPS) is revolutionizing genomics. In this work we use, refine, and develop new tools for the discipline.MPS has led to the discovery of multiple novel subtypes in Acute Lymphoblastic Leukemia (ALL). In Study I we screen for fusion genes in 134 pediatric ALL patients, including patients without an assigned subtype. READ MORE