Search for dissertations about: "Michael Gait"
Found 5 swedish dissertations containing the words Michael Gait.
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1. Structures, toxicity and internalization of cell-penetrating peptides
Abstract : Cellular internalization is a highly regulated process controlled by proteins in the plasma membrane. Large and hydrophilic compounds, in particular, face difficulties conquering the plasma membrane barrier in order to gain access to intracellular environment. This puts serious constrains on the drug industry since many drugs are hydrophilic. READ MORE
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2. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery : Applications and mechanisms
Abstract : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. READ MORE
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3. Cell-penetrating peptides and bioactive cargoes : Strategies and mechanisms
Abstract : The cell membrane is an impermeable barrier for most macromolecules. Recently discovered cell-penetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and even more, carry cargoes with them. How CPPs enter cells is still not clear, while the delivery of different cargoes has been convincingly shown. READ MORE
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4. Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects
Abstract : Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical constituents of WMC are only partially known. READ MORE
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5. Team-based home rehabilitation after hip fracture in older adults : effects, experiences and impact of dementia
Abstract : BACKGROUND: For an older adult a hip fracture may be a traumatic and life-changing event and has shown to be associated with reduced health-related quality of life, disability and increased mortality. Previous rehabilitation studies have often excluded older adults with cognitive impairment and those living in residential care facilities, groups with an additional risk of poor outcome. READ MORE