Search for dissertations about: "Michael Karlsson"

Showing result 1 - 5 of 20 swedish dissertations containing the words Michael Karlsson.

  2. 1. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Author : Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE

  4. 2. Cerebral Mitochondrial Dysfunction and the Development of Targeted Therapeutics

    Author : Michael Karlsson; Mitokondriell Medicin; []
    Keywords : mitochondria; brain; animal models; sepsis; traumatic brain injury; neuroprotection; cyclosporine;

    Abstract : .... READ MORE

  5. 3. Limit Theorems for Ergodic Group Actions and Random Walks

    Author : Michael Björklund; Anders Karlsson; Yves Guivarc'h Irmar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MATHEMATICS; MATEMATIK;

    Abstract : This thesis consists of an introduction, a summary and 7 papers. The papers are devoted to problems in ergodic theory, equidistribution on compact manifolds and random walks on groups. In Papers A and B, we generalize two classical ergodic theorems for actions of abelian groups. READ MORE

  6. 4. Photochemistry of Phenyl Halides

    Author : Daniel Karlsson; Jan Davidsson; Michael Ashfold; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Photochemistry; Predissociation; Phenyl halides; Excited states; Substituent effects; Pump-probe spectroscopy; Molecular beam; Dynamics; Kemi; Chemistry; Kemi;

    Abstract : We have studied fundamental aspects of photo-induced dissociation kinetics and dynamics in several phenyl halides. By combining femtosecond pump-probe measurements with ab initio calculations we are able to account for several observations. READ MORE

  7. 5. Team-based home rehabilitation after hip fracture in older adults : effects, experiences and impact of dementia

    Author : Åsa Karlsson; Nina Lindelöf; Birgitta Olofsson; Michael Stenvall; Yngve Gustafson; Peter Nordström; Anna Cristina Åberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hip fracture; geriatrics; dementia; home rehabilitation; interdisciplinary rehabilitation; walking ability; activities of daily living; recovery; length of stay; accidential falls; qualitative; Geriatrics; geriatrik; Orthopaedics; ortopedi;

    Abstract : BACKGROUND: For an older adult a hip fracture may be a traumatic and life-changing event and has shown to be associated with reduced health-related quality of life, disability and increased mortality. Previous rehabilitation studies have often excluded older adults with cognitive impairment and those living in residential care facilities, groups with an additional risk of poor outcome. READ MORE