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Showing result 1 - 5 of 14 swedish dissertations matching the above criteria.

  2. 1. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

    Author : Dariush Mokhtari; Nils Welsh; Michael Welsh; Anders Tengholm; Shanta Persaud; Uppsala universitet; []
    Keywords : Cell biology; MEKK-1; JNK; human islets; β-cells; siRNA; apoptosis; cell death; MAPK; nitric oxide; cytokines; streptozotocin; c-Rel; NF-κB; Cellbiologi;

    Abstract : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. READ MORE

  4. 2. The importance of substrate metabolism in the regulation of insulin release by mouse pancreatic islets

    Author : Michael Welsh; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  5. 3. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

    Author : Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. READ MORE

  6. 4. 2-ME-Induced Apoptotic Signalling in Prostate Cancer PC3 Cells

    Author : Padideh Davoodpour; Marene Landström; Michael Welsh; Sten Nilsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Prostate cancer; 2-methoxyestradiol; apoptosis; shb; Smad7; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Prostate cancer is common in the Western society and current treatments are often associated with side effects, therefore improved therapeutic strategies are desired. 2-methoxyestradiol (2-ME), an endogenous metabolite of estradiol-17β inhibits tumor growth in vivo as it prevents angiogenesis. 2-ME has also direct cytotoxic effects on tumor cells. READ MORE

  7. 5. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

    Author : Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
    Keywords : Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

    Abstract : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. READ MORE