Search for dissertations about: "Michael Welsh"

Showing result 6 - 10 of 14 swedish dissertations containing the words Michael Welsh.

2. 6. Consequences of Shb Deficiency on Hematopoietic Cell Function

   Author : Karin Gustafsson; Michael Welsh; Martin Bergö; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoiesis; hematopoietic stem cells; myeloid neoplasia; T cells; atopic dermatitis; cell signaling; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. READ MORE

4. 7. The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

   Author : Kristina Holmqvist; Michael Welsh; Eva Degerman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Shb; Src; FAK; Angiogenesis; VEGFR-2; FGFR-1; Endothelial cells; Spreading; Stress fiber formation; siRNA; VEGF; FGF; Differentiation; Migration; Tube formation; RNAi; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Abstract : Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. READ MORE

5. 8. The SHB adaptor protein in human and murine leukemia

   Author : Maria Jamalpour; Michael Welsh; Edvard Smith; Uppsala universitet; []
   Keywords : ;

   Abstract : The SHB adaptor protein operates downstream of tyrosine kinase receptors. It has been found previously that Shb deficiency in hematopoietic stem cells (HSCs) results in less proliferation and failure to maintain the myeloid compartment over time. READ MORE

6. 9. The Role of the SHB Adapter Protein in Cell Differentiation and Development

   Author : Vitezslav Kriz; Michael Welsh; Urban Lendahl; Uppsala universitet; []
   Keywords : Cell biology; SHB; transgene; ES cells; cavitation; knockout; mouse; vasculogenesis; hematopoiesis; endoderm; mesoderm; malformation; Cellbiologi;

   Abstract : The present study was conducted in order to assess a role of the SH2 domain-containing adapter protein SHB in development and cell differentiation.Embryonic stem (ES) cells overexpressing SHB and SHB with an inactive SH2 domain (R522K-SHB) were obtained. READ MORE

7. 10. Roles of the Shb and Cbl Proteins in Signal Transduction and Blood Vessel Formation

   Author : Lingge Lu; Michael Welsh; Lars Holgren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Shb; Cbl; FGF-2; NGF; PDGF; VEGF; VEGFR-2; differentiation; blood vessel formation; PC12 cells; endothelial cells; embryoid bodies; Rap1; CrkII; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Formation of blood vessels occurs through two processes: vasculogenesis and angiogenesis, which are regulated by various growth factors such as vascular endothelial growth factor, fibroblast growth factor and platelet-derived growth factor. The present study was carried out in order to investigate the roles of the Shb and Cbl proteins in growth factor-mediated signal transduction and blood vessel formation. READ MORE