Search for dissertations about: "Michael Williams"

Showing result 1 - 5 of 7 swedish dissertations containing the words Michael Williams.

2. 1. The role of HMG-coenzyme A reductase (HMGCR) and statin medication in the Central Nervous System : Cognitive Functions, Metabolism, Feeding and Sleep Behaviour

   Author : Ahmed Alsehli; Helgi B. Schiöth; Michael J. Williams; Heinrich Dircksen; Uppsala universitet; []
   Keywords : Statin; cardiovascular disease; HMGCR; PCSK9; sleep; insomnia; circadian; Chronotype; feeding;

   Abstract : Millions of people are currently on statin medications (HMGCR inhibitors) to prevent cardiovascular diseases. Despite considerable central nervous system expression, little is known about HMGCR function in the brain. READ MORE

4. 2. Exposure to xenobiotic chemicals disrupts metabolism, rhythmicity and cell proliferation in Drosophila melanogaster

   Author : Hao Cao; Helgi B. Schiöth; Michael J. Williams; Jan Larsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; xenobiotics; metabolism; insulin signalling; circadian rhythm; carcinogen; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

   Abstract : Most species are constantly exposed to xenobiotic chemicals through multiple routes. Among all categories of xenobiotics, phthalates and bisphenols are two of the most widely used plasticizers and can be found in polyvinyl chloride (PVC) materials, medical devices and even drinking water. READ MORE

5. 3. The Molecular Mechanism of Aggression and Feeding Behaviour in Drosophila melanogaster

   Author : Philip Goergen; Helgi Schiöth; Michael Williams; Simon Tuck; Uppsala universitet; []
   Keywords : Drosophila; aggression; obesity; homeostasis;

   Abstract : Obesity is a complex disorder which has become a growing health concern. Twin studies have demonstrated a strong genetic component to the development of obesity and genome wide association studies have identified several genetic loci associated with it. However, most of these loci are still poorly understood in a functional context. READ MORE

6. 4. Non-caloric regulation of food intake

   Author : Anica Klockars; Dan Larhammar; Michael Williams; Robert Fredriksson; Karolina Skibicka; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroscience; Neurovetenskap;

   Abstract : Food intake is shaped by environmental, endocrine, metabolic, and reward-related signals. A change in appetite is an outcome of integration of the relevant external and internal stimuli. While the main purpose of eating is to reverse a negative energy balance, mechanisms protecting homeostasis change appetite for other reasons. READ MORE

7. 5. Hematopoiesis in a Crustacean

   Author : Xionghui Lin; Irene Söderhäll; Kenneth Söderhäll; Michael J. Williams; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; astakine; cytokine; hematopoiesis; prokineticin; transglutaminase; ATP synthase; innate immunity; apoptosis; Immunology; Immunologi; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

   Abstract : Hemocytes (blood cells) play an important role in the immune response in invertebrates, and thus the regulation of hemocyte homeostasis (hematopoiesis) is essential for the host survival against pathogens. Astakine 1, a homologue to vertebrate prokineticins, was first identified in the freshwater crayfish Pacifastacus leniusculus as a cytokine, and was found to be necessary for new hemocyte synthesis and release in vivo, and also to induce spreading and proliferation of Hematopoietic tissue cells (Hpt cells, precursor of hemocytes) in vitro. READ MORE