Search for dissertations about: "Microbioreactors"

Found 3 swedish dissertations containing the word Microbioreactors.

  2. 1. Tools for the development of intensified perfusion processes for mammalian cell culture

    Author : Hubert Schwarz; Véronique Chotteau; Mark Smales; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinant protein biomanufacturing; Perfusion process; Integrated continuous bioprocessing; Monoclonal antibody; Erythropoietin; Chinese Hamster Ovary cells; Human Embryonic Kidney cells; Perfusion medium optimization; Cell specific perfusion rate; Raman spectroscopy; N-glycosylation; Microbioreactors; Design of Experiments; Biotechnology; Bioteknologi;

    Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE

  4. 2. Porous Silicon Microbioreactors - Applications and Technology

    Author : Martin Bengtsson; Avdelningen för Biomedicinsk teknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Elektroteknik; Electrical engineering; immobilised cells; enzyme reactor; micro fluidics; Microreactor; porous silicon;

    Abstract : Microfluidic systems have become one of the most interesting fields in the research of chemical analysis. Miniaturized systems exhibit numerous practical advantages when compared with traditional batch-scale synthesis such as lower sample volumes, increased control of the reactions and higher sample throughput. READ MORE

  5. 3. Organs-on-chips for the pharmaceutical development process : design perspectives and implementations

    Author : Jonas Christoffersson; Carl-Fredrik Mandenius; Danny van Noort; Peter Sartipy; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Organs-on-chips; cell culture models; pharmaceutical development; microfluidics;

    Abstract : Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. READ MORE