Search for dissertations about: "Microglial activation"

Showing result 11 - 15 of 60 swedish dissertations containing the words Microglial activation.

  2. 11. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

    Author : Hanna Wootz; Dan Lindholm; Håkan Aldskogius; Christopher Fowler; Uppsala universitet; []
    Keywords : Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. READ MORE

  4. 12. Neuroinflammation in Alzheimer's disease : Focus on NF-κB and C/EBP transcription factors

    Author : Veronica Ramberg; Kerstin Iverfeldt; Josep Saura; Stockholms universitet; []
    Keywords : Alzheimer’s disease; neuroinflammation; NF-κB; C EBP; apoptosis; caspases; FRET; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : Alzheimer's disease (AD) is the most common form of dementia among elderly. The disease is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic neuroinflammation. READ MORE

  5. 13. Deciphering microglia plasticity in glioma

    Author : Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. READ MORE

  6. 14. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

    Author : Edoardo Brandi; Neural plasticitet och reparation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

    Abstract : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. READ MORE

  7. 15. Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link

    Author : Giacomo Gravina; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S. epidermidis; neonatal brain injury; hypoxia-ischemia; microglia; neuroinflammation; S. epidermidis; neonatal brain injury; hypoxia-ischemia; microglia; neuroinflammation;

    Abstract : Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher susceptibility to infections, which puts them at a higher risk of developing neurological impairments as well as neurodevelopmental diseases. READ MORE