Search for dissertations about: "Microglial activation"

Showing result 16 - 20 of 53 swedish dissertations containing the words Microglial activation.

  1. 16. Glial cell responses, complement and clusterin expression after lesions in central or peripheral nervous system

    Author : Li Liu; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Glia; Complement; Clusterin; Proliferation; Peripheral nerve injury; Spinal cord injury; Rhizotomy; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : The present Thesis examines the expression and role of complement and the complement regulator clusterin after central or peripheral axon injury in relation to the responses of non-neuronal cells. Following peripheral sensory nerve injury, complement was expressed in the spinal cord and brain stem in association with reactive microglia, which also appeared to be a local source of complement. READ MORE

  2. 17. The role of myeloid cells in neurodegenerative diseases. Studies on cellular phenotype and communication

    Author : Yiyi Yang; Neuroinflammation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microglia; Neuroinflammation; Alzherimer’s disease; Stroke; Innate immune system; Systemic inflammation; Monocytes; Single-cell sequencing;

    Abstract : Neurological disorders are listed as the second leading cause of death worldwide. Stroke and Alzheimer’s disease (AD) are the major contributors to neurological disorders of deaths. Every year, around 14 million new people are affected by stoke and nearly 10 million new cases of AD are diagonosed worldwide. READ MORE

  3. 18. Resolution of inflammation as a therapeutic target for Alzheimer's disease

    Author : Mingqin Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, clinically manifested by memory impairment, loss of ability in conducting daily activity and increased need for care, thus causing immense suffering for the afflicted and relatives, as well as a huge economic burden to the society. Despite the existence of symptom-relieving drugs, there is no drug that can stop the progression or cure the disease. READ MORE

  4. 19. Astroglial Cells : Role in Neurodegenerative-Inflammatory Processes in the Central Nervous System

    Author : Gun Eriksson; Karl Åkerman; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; Kemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Abstract : Inflammatory processes, mediated by the pro-inflammatory cytokines interleukin (IL) -1a/b, tumor necrosis factora(TNFa), IL-6 and excitotoxic actions of glutamate, are proposed to be implicated in neurodegenerative diseases, such as Alzheimer's disease.A neurotoxic fragment ofb-amyloid,bA25-35, was shown to induce a reactive phenotype of primary astrocytes and microglial cells in a time-dependent manner. READ MORE

  5. 20. Role of cytokines in experimental neurodegenerative and neuroinflammatory disorders

    Author : Xing-Mei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Altered expression of cytokines in response to body injury has diverse actions that can exacerbate, mediate, reduce or inhibit neuronal and myelin damage as well as influence the disease development in a variety of nervous system disorders, such as Alzheimer s disease (AD), multiple sclerosis and Guillain-Barré Syndrome (GBS). In these studies, we attempted to explore the possible roles of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in experimental neurodegenerative and neuroinflammatory disorders. READ MORE